Sensitivity to ultraviolet radiation of Lassa, vaccinia, and Ebola viruses dried on surfaces

Germicidal UV (also known as UVC) provides a means to decontaminate infected environments as well as a measure of viral sensitivity to sunlight. The present study determined UVC inactivation slopes (and derived D₃₇ values) of viruses dried onto nonporous (glass) surfaces. The data obtained indicate...

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Bibliographic Details
Published in:Archives of virology 2011-03, Vol.156 (3), p.489-494
Main Authors: Sagripanti, Jose-Luis, Lytle, C. David
Format: Article
Language:English
Subjects:
Biodefense
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Brief Report
Desiccation
Disease resistance
Ebola
Ebola virus
Ebolavirus
Ebolavirus - radiation effects
Environmental inactivation
Environmental Microbiology
Fundamental and applied biological sciences. Psychology
Glass
Humans
Infectious Diseases
Inoculum
Lassa
Lassa virus
Lassa virus - radiation effects
Medical Microbiology
Microbial fate
Microbiology
Miscellaneous
Smallpox
Ultraviolet radiation
Ultraviolet Rays
UVC radiation
Vaccinia
Vaccinia virus
Vaccinia virus - radiation effects
Variola virus
Viral persistence
Virions
Virology
Viruses
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Summary:Germicidal UV (also known as UVC) provides a means to decontaminate infected environments as well as a measure of viral sensitivity to sunlight. The present study determined UVC inactivation slopes (and derived D₃₇ values) of viruses dried onto nonporous (glass) surfaces. The data obtained indicate that the UV resistance of Lassa virus is higher than that of Ebola virus. The UV sensitivity of vaccinia virus (a surrogate for variola virus) appeared intermediate between that of the two virulent viruses studied. In addition, the three viruses dried on surfaces showed a relatively small but significant population of virions (from 3 to 10 % of virus in the inoculum) that appeared substantially more protected by their environment from the effect of UV than the majority of virions tested. The findings reported in this study should assist in estimating the threat posed by the persistence of virus in environments contaminated during epidemics or after an accidental or intentional release.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-010-0847-1