Routes to manipulate MHC class II antigen presentation

MHC class II molecules (MHC-II) present antigenic fragments acquired in the endocytic route to the immune system for recognition and activation of CD4+ T cells. This ignites a series of immune responses. MHC-II strongly correlates to most autoimmune diseases. Understanding the biology of MHC-II is t...

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Bibliographic Details
Published in:Current opinion in immunology 2011-02, Vol.23 (1), p.88-95
Main Authors: van den Hoorn, Tineke, Paul, Petra, Jongsma, Marlieke LM, Neefjes, Jacques
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antigen Presentation
Cell Membrane - immunology
Cell Membrane - metabolism
Histocompatibility Antigens Class II - immunology
Histocompatibility Antigens Class II - metabolism
Humans
Protein Transport
Vaccination
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Summary:MHC class II molecules (MHC-II) present antigenic fragments acquired in the endocytic route to the immune system for recognition and activation of CD4+ T cells. This ignites a series of immune responses. MHC-II strongly correlates to most autoimmune diseases. Understanding the biology of MHC-II is therefore expected to translate into novel means of autoimmunity control or immune response improvement. Although the basic cell biology of MHC-II antigen presentation is well understood, many novel aspects have been uncovered in recent years including means of antigen delivery, preparation for MHC-II loading, transport processes and vaccination strategies. We will discuss past, present and future of these insights into the biology of MHC-II.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2010.11.002