Central pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) decrease the baroreflex sensitivity in trout

Highlights ► First report in any vertebrate on central PACAP and VIP on baroreflex. ► Transfer function analysis of cardiac baroreflex sensitivity in trout. ► Central PACAP and VIP dose-dependently reduce the cardiac baroreflex sensitivity.

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Bibliographic Details
Published in:General and comparative endocrinology 2011-04, Vol.171 (2), p.245-251
Main Authors: Lancien, Frédéric, Mimassi, Nagi, Conlon, J. Michael, Mével, Jean-Claude Le
Format: Article
Language:English
Subjects:
algorithms
Animals
Baroreflex
Baroreflex - drug effects
blood pressure
blood vessels
electrocardiography
Endocrinology & Metabolism
heart
homeostasis
Intra-arterial injection
Intracerebroventricular injection
Oncorhynchus mykiss
PACAP
Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology
polypeptides
R–R interval and systolic blood pressure variabilities
Teleost
Transfer function analysis
Trout
vasoactive intestinal peptide
Vasoactive Intestinal Peptide - pharmacology
VIP
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Description
Summary:Highlights ► First report in any vertebrate on central PACAP and VIP on baroreflex. ► Transfer function analysis of cardiac baroreflex sensitivity in trout. ► Central PACAP and VIP dose-dependently reduce the cardiac baroreflex sensitivity.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2011.02.006