Generation of the CF3 radical from trifluoromethylsulfonium triflate and its trifluoromethylation of styrenes

The CF(3) radical was generated from the reaction of S-(trifluoromethyl)diphenylsulfonium triflate with Na(2)S(2)O(4) or HOCH(2)SO(2)Na under suitable conditions without further reduction. Based on this, a method for the synthesis of α-trifluoromethylated ketones has been successfully developed.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2011-01, Vol.47 (23), p.6632-6634
Main Authors: Zhang, Cheng-Pan, Wang, Zong-Ling, Chen, Qing-Yun, Zhang, Chun-Tao, Gu, Yu-Cheng, Xiao, Ji-Chang
Format: Article
Language:English
Subjects:
Fluorine - chemistry
Free Radicals - chemistry
Ketones
Mesylates - chemistry
Oxidation-Reduction
Radicals
Reduction
Styrenes
Styrenes - chemistry
Sulfates - chemistry
Synthesis
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Summary:The CF(3) radical was generated from the reaction of S-(trifluoromethyl)diphenylsulfonium triflate with Na(2)S(2)O(4) or HOCH(2)SO(2)Na under suitable conditions without further reduction. Based on this, a method for the synthesis of α-trifluoromethylated ketones has been successfully developed.
ISSN:1359-7345
1364-548X
DOI:10.1039/c1cc11765c