Dehydrocostus lactone prevents mitochondrial dysfunction in osteoblastic MC3T3-E1 cells

The dried root of Saussurea lappa Clarke (Compositae) has been used as a traditional medicine. Dehydrocostus lactone is one of the main bioactive constituents of this medicinal plant. In the present study, the protective effect of dehydrocostus lactone against antimycin A (an inhibitor of mitochondr...

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Bibliographic Details
Published in:European journal of pharmacology 2011-08, Vol.664 (1), p.1-7
Main Author: Choi, Eun Mi
Format: Article
Language:English
Subjects:
3T3 Cells
Animals
Antimycin A - toxicity
Biological and medical sciences
Calcium - metabolism
Cytoprotection - drug effects
Dehydrocostus lactone
Intracellular Space - drug effects
Intracellular Space - metabolism
Lactones - pharmacology
Medical sciences
Mice
Mitochondria - drug effects
Mitochondria - pathology
Mitochondrial dysfunction
Osteoblastic MC3T3-E1 cells
Osteoblasts - cytology
Osteoblasts - drug effects
Osteoblasts - pathology
Pharmacology. Drug treatments
Potassium - metabolism
Sesquiterpenes - pharmacology
Superoxides - metabolism
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Summary:The dried root of Saussurea lappa Clarke (Compositae) has been used as a traditional medicine. Dehydrocostus lactone is one of the main bioactive constituents of this medicinal plant. In the present study, the protective effect of dehydrocostus lactone against antimycin A (an inhibitor of mitochondrial complex III)-induced cytotoxicity was investigated in osteoblastic MC3T3-E1 cells. Pre-treatment with dehydrocostus lactone prior to antimycin A exposure significantly prevented mitochondrial membrane potential dissipation, complex IV inactivation, ATP loss, cytochrome c release, intracellular calcium elevation and potassium loss, and reactive oxygen species production induced by antimycin A. These results suggest that dehydrocostus lactone protects osteoblastic MC3T3-E1 cells from antimycin A-induced cell damage through the improved mitochondrial function. [Display omitted]
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2011.05.005