Preparation of magnetite aqueous dispersion for magnetic fluid hyperthermia

An aqueous magnetic suspension was prepared by dispersing amphiphilic co-polymer-coated monodispersed magnetite nanoparticles synthesized through thermal decomposition of iron acetylacetonate (Fe(acac) 3) in a mixture of oleic acid and oleylamine. The average diameter of narrow-size-distributed magn...

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Bibliographic Details
Published in:Journal of magnetism and magnetic materials 2011-05, Vol.323 (10), p.1216-1222
Main Authors: Kikuchi, Teppei, Kasuya, Ryo, Endo, Shota, Nakamura, Akira, Takai, Toshiyuki, Metzler-Nolte, Nils, Tohji, Kazuyuki, Balachandran, Jeyadevan
Format: Article
Language:English
Subjects:
Biomolecules
Chemistry
Colloidal state and disperse state
Copolymers
Dispersing
Dispersions
Ethers
Exact sciences and technology
General and physical chemistry
Magnetic fluid hyperthermia
Magnetite
Nanoparticles
Oleic acid
Physical and chemical studies. Granulometry. Electrokinetic phenomena
Polyethylenes
Surface modification
Thermal decomposition
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Summary:An aqueous magnetic suspension was prepared by dispersing amphiphilic co-polymer-coated monodispersed magnetite nanoparticles synthesized through thermal decomposition of iron acetylacetonate (Fe(acac) 3) in a mixture of oleic acid and oleylamine. The average diameter of narrow-size-distributed magnetite nanoparticles varied between 5 and 12 nm depending on the experimental parameters such as reaction temperature, metal salt concentration and oleic acid/oleylamine ratio. Though the as-synthesized particles were coated with oleate and were dispersible in organic solvent, their surfaces were modified using amphiphilic co-polymers composed of poly(maleic anhydride-alt-1-octadecene) and polyethylene glycol-methyl ether and made dispersible in water. Infrared spectra of the sample indicated the existence of −COOH groups on the surface for further conjugation with biomolecules for targeted cancer therapy. ► Preparation of magnetite nanoparticles suitable for in vivo magnetic fluid hyperthermia. ► Thermal decomposition of Fe(acac) 3 in a mixture of oleic acid and oleylamine. ► Monodispersed magnetite particles with average sizes varying between 5 and 12 nm. ► Modification of the hydrophobic particle surface with amphiphilic co-polymers. ► These surface modified particles have carboxyl groups and polyethylene glycol.
ISSN:0304-8853
DOI:10.1016/j.jmmm.2010.11.009