Demyelination and degeneration in the injured human spinal cord detected with diffusion and magnetization transfer MRI

Characterizing demyelination/degeneration of spinal pathways in traumatic spinal cord injured (SCI) patients is crucial for assessing the prognosis of functional rehabilitation. Novel techniques based on diffusion-weighted (DW) magnetic resonance imaging (MRI) and magnetization transfer (MT) imaging...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2011-04, Vol.55 (3), p.1024-1033
Main Authors: Cohen-Adad, J., El Mendili, M-M., Lehéricy, S., Pradat, P-F., Blancho, S., Rossignol, S., Benali, H.
Format: Article
Language:English
Subjects:
Adult
Age
Aged
ASIA
Atrophy
Demyelinating Diseases - pathology
Diffusion
Diffusion Magnetic Resonance Imaging - methods
Diffusion-weighted MRI
Disability Evaluation
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging - methods
Magnetization transfer
Male
Middle Aged
Neurodegenerative Diseases - pathology
NMR
Nuclear magnetic resonance
Pathology
Spinal cord
Spinal Cord - pathology
Spinal Cord Injuries - pathology
Spinal cord injury
Young Adult
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Summary:Characterizing demyelination/degeneration of spinal pathways in traumatic spinal cord injured (SCI) patients is crucial for assessing the prognosis of functional rehabilitation. Novel techniques based on diffusion-weighted (DW) magnetic resonance imaging (MRI) and magnetization transfer (MT) imaging provide sensitive and specific markers of white matter pathology. In this paper we combined for the first time high angular resolution diffusion-weighted imaging (HARDI), MT imaging and atrophy measurements to evaluate the cervical spinal cord of fourteen SCI patients and age-matched controls. We used high in-plane resolution to delineate dorsal and ventrolateral pathways. Significant differences were detected between patients and controls in the normal-appearing white matter for fractional anisotropy (FA, p
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2010.11.089