Improvement of the durability of porous silicon through functionalisation for biomedical applications

The durability of porous silicon (PS) in solutions was improved by grafting a molecule, 2,4,6,8-tetramethyl-2,4,6,8-tetravinyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane (TE), with four terminal vinyl groups. With a native PS sample as control, we compared the long-term durability of three modified PS sa...

Full description

Saved in:
Bibliographic Details
Published in:Thin solid films 2011-03, Vol.519 (10), p.3325-3333
Main Authors: Han, H.-M., Li, H.-F., Xiao, S.-J.
Format: Article
Language:English
Subjects:
Binding
Biological and medical sciences
Degradation
Durability
Grafting
Medical sciences
Microarray
Phosphates
Polystyrene resins
Porous silicon
Protective coatings
Proteins
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Saline
Technology. Biomaterials. Equipments. Material. Instrumentation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The durability of porous silicon (PS) in solutions was improved by grafting a molecule, 2,4,6,8-tetramethyl-2,4,6,8-tetravinyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane (TE), with four terminal vinyl groups. With a native PS sample as control, we compared the long-term durability of three modified PS samples: TE-, undec-10-enoic acid (UA)-, and TE/UA(TE first and UA followed)-grafted PS, in a weak organic base of dimethyl sulfoxide, an aqueous mineral solution of CuBr 2, and phosphate buffered saline respectively. Results indicate that TE-grafting is a straightforward and impactful approach to protect PS from oxidation and degradation. Further we used the TE-grafted PS to fabricate a prototype protein microarray by post-grafting UA and subsequently converting UA to nitrilotriacetic acid/Ni 2+ for binding histidine-tagged proteins.
ISSN:0040-6090
1879-2731
DOI:10.1016/j.tsf.2010.12.015