Role of apolipoprotein E in renal damage protection

It is well-known that nephrotic syndrome and chronic renal failure are associated with lipid and lipoprotein abnormalities. For a long time, it has been thought that hyperlipidemia is a secondary and insignificant condition of these renal injuries. Recently, it has been shown that dyslipidaemia may...

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Bibliographic Details
Published in:Histochemistry and cell biology 2011-06, Vol.135 (6), p.571-579
Main Authors: Bonomini, F., Rodella, L. F., Moghadasian, M., Lonati, C., Coleman, R., Rezzani, R.
Format: Article
Language:English
Subjects:
Aging
Aging - genetics
Animals
Apolipoproteins
Apolipoproteins E - genetics
Apolipoproteins E - metabolism
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Developmental Biology
Hyperlipidemias - metabolism
Hyperlipidemias - pathology
Kidney
Kidney diseases
Kidney Failure, Chronic - metabolism
Lipids
Mice
Mice, Inbred C57BL
Mice, Knockout
NF-kappa B - metabolism
Original Paper
Oxidative Stress - genetics
Rodents
Tumor Necrosis Factor-alpha - metabolism
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Summary:It is well-known that nephrotic syndrome and chronic renal failure are associated with lipid and lipoprotein abnormalities. For a long time, it has been thought that hyperlipidemia is a secondary and insignificant condition of these renal injuries. Recently, it has been shown that dyslipidaemia may contribute to the development and progression of chronic kidney disease. Apolipoprotein E (apoE) null mice are a very popular model for studying spontaneous hypercholesterolemia, but only limited data are available for the role of apolipoprotein E in kidney disease. The purpose of this study is to evaluate kidney disease in apolipoprotein E deficient mice. For this study, apoE null mice and control mice at different ages (6 weeks and 15 months) were used. Kidney morphological damage and proteins involved in oxidative stress and aging (TNF-α and NF-kB) were analyzed. ApoE deficient mice have morphological alterations that are the hallmark of kidney pathogenesis, which increase with the age of the animals. In apoE null mice kidneys, there is also increased oxidative stress as compared to control mice at the same age and fewer antioxidant enzymes. Our findings add to the growing list of protective effects that apoE possesses.
ISSN:0948-6143
1432-119X
DOI:10.1007/s00418-011-0815-1