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Mammographic morphology and distribution of calcifications in ductal carcinoma in situ diagnosed in organized screening
Background Ductal carcinoma in situ of the breast (DCIS) represents a challenge in mammographic screening due to its unknown progression into invasive cancer. The majority of the DCIS is detected due to signs of calcifications on the mammograms. Purpose To analyze the combinations of mammographic mo...
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Published in: | Acta radiologica (1987) 2011-06, Vol.52 (5), p.481-487 |
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container_title | Acta radiologica (1987) |
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creator | Hofvind, Solveig Iversen, Barbro F Eriksen, Liv Styr, Bodil M Kjellevold, Kjell Kurz, Kathinka D |
description | Background
Ductal carcinoma in situ of the breast (DCIS) represents a challenge in mammographic screening due to its unknown progression into invasive cancer. The majority of the DCIS is detected due to signs of calcifications on the mammograms.
Purpose
To analyze the combinations of mammographic morphology and distribution of calcifications by Van Nuys nuclear grade (grade).
Material and Methods
A total of 217 DCIS diagnosed in women aged 50–69 years old who participated in the Norwegian Breast Cancer Screening Program in the period November 1995 to December 2007 were reviewed by four breast imaging specialists. The mammograms were classified according to the morphology and distribution of the calcifications, using BI-RADS nomenclature. Chi square test was used to compare the groups of morphology and distribution by grade.
Results
Calcifications were identified in 93% (202/217) of the cases, 15% (30/202) as grade 1 and 74% (149/202) as grade 3. Fine pleomorphic calcifications were seen in 38% (77/202) of the lesions and fine linear and fine linear branching in 31% (62/202). Sixty-nine percent (53/77) of the fine pleomorphic and 84% (52/62) of the fine linear and fine linear branching calcifications were high grade lesions. Grouped distribution was seen in about half of all the cases (104/202). Among the high grade lesions with fine pleomorphic or fine linear and fine linear branching calcifications, 75% (40/53) and 69% (36/52), respectively, had grouped or segmental distribution.
Conclusion
DCIS presented overlapping groups of morphology and distribution of calcification by grade, but fine pleomorphic and fine linear and fine linear branching calcifications with grouped and segmental distributions were associated with high grade DCIS. Seeking for further knowledge that allows separation of non-high grade from high grade DCIS has to continue to improve the quality of mammographic screening. |
doi_str_mv | 10.1258/ar.2011.100357 |
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fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_870290065</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1258_ar.2011.100357</sage_id><sourcerecordid>870290065</sourcerecordid><originalsourceid>FETCH-LOGICAL-c360t-997231369e222a999737790d6922f6179ab8911d0913262f9253c3b900c3f90f3</originalsourceid><addsrcrecordid>eNp1kE1v1DAQhi1ERbeFK0eUC-JQZTtjb-L4iCq-pCIu5WzNOnbqKrEXO1HV_noc7QInTqN555kZ6WHsLcIWedNdU9pyQNwigGjkC7bBFqCGXdO8ZBvg3a7GrsFzdpHzAwBy2eArds5xpzoB7YY9fqdpikOiw7031RTT4T6OcXiqKPRV7_Oc_H6ZfQxVdJWh0XjnDa1Brnyo-sXMNJZBMj7EidYs-3kpqzSEmG2_JjENFPxzabJJ1gYfhtfszNGY7ZtTvWQ_P3-6u_la3_748u3m421tRAtzrZTkAkWrLOecVGmFlAr6VnHuWpSK9p1C7EGh4C13ijfCiL0CMMIpcOKSfTjePaT4a7F51pPPxo4jBRuXrDsJvNBtU8jtkTQp5pys04fkJ0pPGkGvrjUlvbrWR9dl4d3p9LKfbP8X_yO3AO9PAOWiziUKxud_3I6DlLh-vjpymQarH-KSQlHyv7e_AS3blHA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>870290065</pqid></control><display><type>article</type><title>Mammographic morphology and distribution of calcifications in ductal carcinoma in situ diagnosed in organized screening</title><source>SAGE</source><creator>Hofvind, Solveig ; Iversen, Barbro F ; Eriksen, Liv ; Styr, Bodil M ; Kjellevold, Kjell ; Kurz, Kathinka D</creator><creatorcontrib>Hofvind, Solveig ; Iversen, Barbro F ; Eriksen, Liv ; Styr, Bodil M ; Kjellevold, Kjell ; Kurz, Kathinka D</creatorcontrib><description>Background
Ductal carcinoma in situ of the breast (DCIS) represents a challenge in mammographic screening due to its unknown progression into invasive cancer. The majority of the DCIS is detected due to signs of calcifications on the mammograms.
Purpose
To analyze the combinations of mammographic morphology and distribution of calcifications by Van Nuys nuclear grade (grade).
Material and Methods
A total of 217 DCIS diagnosed in women aged 50–69 years old who participated in the Norwegian Breast Cancer Screening Program in the period November 1995 to December 2007 were reviewed by four breast imaging specialists. The mammograms were classified according to the morphology and distribution of the calcifications, using BI-RADS nomenclature. Chi square test was used to compare the groups of morphology and distribution by grade.
Results
Calcifications were identified in 93% (202/217) of the cases, 15% (30/202) as grade 1 and 74% (149/202) as grade 3. Fine pleomorphic calcifications were seen in 38% (77/202) of the lesions and fine linear and fine linear branching in 31% (62/202). Sixty-nine percent (53/77) of the fine pleomorphic and 84% (52/62) of the fine linear and fine linear branching calcifications were high grade lesions. Grouped distribution was seen in about half of all the cases (104/202). Among the high grade lesions with fine pleomorphic or fine linear and fine linear branching calcifications, 75% (40/53) and 69% (36/52), respectively, had grouped or segmental distribution.
Conclusion
DCIS presented overlapping groups of morphology and distribution of calcification by grade, but fine pleomorphic and fine linear and fine linear branching calcifications with grouped and segmental distributions were associated with high grade DCIS. Seeking for further knowledge that allows separation of non-high grade from high grade DCIS has to continue to improve the quality of mammographic screening.</description><identifier>ISSN: 0284-1851</identifier><identifier>EISSN: 1600-0455</identifier><identifier>DOI: 10.1258/ar.2011.100357</identifier><identifier>PMID: 21498306</identifier><identifier>CODEN: ACRAE3</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Aged ; Biological and medical sciences ; Breast Neoplasms - diagnostic imaging ; Breast Neoplasms - epidemiology ; Breast Neoplasms - pathology ; Calcinosis - diagnostic imaging ; Calcinosis - epidemiology ; Calcinosis - pathology ; Carcinoma, Intraductal, Noninfiltrating - diagnostic imaging ; Carcinoma, Intraductal, Noninfiltrating - epidemiology ; Carcinoma, Intraductal, Noninfiltrating - pathology ; Chi-Square Distribution ; Early Detection of Cancer ; Female ; Genital system. Mammary gland ; Humans ; Incidence ; Investigative techniques, diagnostic techniques (general aspects) ; Mammography - methods ; Mass Screening ; Medical sciences ; Middle Aged ; Norway - epidemiology ; Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><ispartof>Acta radiologica (1987), 2011-06, Vol.52 (5), p.481-487</ispartof><rights>2011 The Foundation Acta Radiologica</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-997231369e222a999737790d6922f6179ab8911d0913262f9253c3b900c3f90f3</citedby><cites>FETCH-LOGICAL-c360t-997231369e222a999737790d6922f6179ab8911d0913262f9253c3b900c3f90f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925,79364</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24207715$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21498306$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hofvind, Solveig</creatorcontrib><creatorcontrib>Iversen, Barbro F</creatorcontrib><creatorcontrib>Eriksen, Liv</creatorcontrib><creatorcontrib>Styr, Bodil M</creatorcontrib><creatorcontrib>Kjellevold, Kjell</creatorcontrib><creatorcontrib>Kurz, Kathinka D</creatorcontrib><title>Mammographic morphology and distribution of calcifications in ductal carcinoma in situ diagnosed in organized screening</title><title>Acta radiologica (1987)</title><addtitle>Acta Radiol</addtitle><description>Background
Ductal carcinoma in situ of the breast (DCIS) represents a challenge in mammographic screening due to its unknown progression into invasive cancer. The majority of the DCIS is detected due to signs of calcifications on the mammograms.
Purpose
To analyze the combinations of mammographic morphology and distribution of calcifications by Van Nuys nuclear grade (grade).
Material and Methods
A total of 217 DCIS diagnosed in women aged 50–69 years old who participated in the Norwegian Breast Cancer Screening Program in the period November 1995 to December 2007 were reviewed by four breast imaging specialists. The mammograms were classified according to the morphology and distribution of the calcifications, using BI-RADS nomenclature. Chi square test was used to compare the groups of morphology and distribution by grade.
Results
Calcifications were identified in 93% (202/217) of the cases, 15% (30/202) as grade 1 and 74% (149/202) as grade 3. Fine pleomorphic calcifications were seen in 38% (77/202) of the lesions and fine linear and fine linear branching in 31% (62/202). Sixty-nine percent (53/77) of the fine pleomorphic and 84% (52/62) of the fine linear and fine linear branching calcifications were high grade lesions. Grouped distribution was seen in about half of all the cases (104/202). Among the high grade lesions with fine pleomorphic or fine linear and fine linear branching calcifications, 75% (40/53) and 69% (36/52), respectively, had grouped or segmental distribution.
Conclusion
DCIS presented overlapping groups of morphology and distribution of calcification by grade, but fine pleomorphic and fine linear and fine linear branching calcifications with grouped and segmental distributions were associated with high grade DCIS. Seeking for further knowledge that allows separation of non-high grade from high grade DCIS has to continue to improve the quality of mammographic screening.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Breast Neoplasms - pathology</subject><subject>Calcinosis - diagnostic imaging</subject><subject>Calcinosis - epidemiology</subject><subject>Calcinosis - pathology</subject><subject>Carcinoma, Intraductal, Noninfiltrating - diagnostic imaging</subject><subject>Carcinoma, Intraductal, Noninfiltrating - epidemiology</subject><subject>Carcinoma, Intraductal, Noninfiltrating - pathology</subject><subject>Chi-Square Distribution</subject><subject>Early Detection of Cancer</subject><subject>Female</subject><subject>Genital system. Mammary gland</subject><subject>Humans</subject><subject>Incidence</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Mammography - methods</subject><subject>Mass Screening</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Norway - epidemiology</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><issn>0284-1851</issn><issn>1600-0455</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp1kE1v1DAQhi1ERbeFK0eUC-JQZTtjb-L4iCq-pCIu5WzNOnbqKrEXO1HV_noc7QInTqN555kZ6WHsLcIWedNdU9pyQNwigGjkC7bBFqCGXdO8ZBvg3a7GrsFzdpHzAwBy2eArds5xpzoB7YY9fqdpikOiw7031RTT4T6OcXiqKPRV7_Oc_H6ZfQxVdJWh0XjnDa1Brnyo-sXMNJZBMj7EidYs-3kpqzSEmG2_JjENFPxzabJJ1gYfhtfszNGY7ZtTvWQ_P3-6u_la3_748u3m421tRAtzrZTkAkWrLOecVGmFlAr6VnHuWpSK9p1C7EGh4C13ijfCiL0CMMIpcOKSfTjePaT4a7F51pPPxo4jBRuXrDsJvNBtU8jtkTQp5pys04fkJ0pPGkGvrjUlvbrWR9dl4d3p9LKfbP8X_yO3AO9PAOWiziUKxud_3I6DlLh-vjpymQarH-KSQlHyv7e_AS3blHA</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Hofvind, Solveig</creator><creator>Iversen, Barbro F</creator><creator>Eriksen, Liv</creator><creator>Styr, Bodil M</creator><creator>Kjellevold, Kjell</creator><creator>Kurz, Kathinka D</creator><general>SAGE Publications</general><general>Royal Society of Medicine</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110601</creationdate><title>Mammographic morphology and distribution of calcifications in ductal carcinoma in situ diagnosed in organized screening</title><author>Hofvind, Solveig ; Iversen, Barbro F ; Eriksen, Liv ; Styr, Bodil M ; Kjellevold, Kjell ; Kurz, Kathinka D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-997231369e222a999737790d6922f6179ab8911d0913262f9253c3b900c3f90f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Breast Neoplasms - diagnostic imaging</topic><topic>Breast Neoplasms - epidemiology</topic><topic>Breast Neoplasms - pathology</topic><topic>Calcinosis - diagnostic imaging</topic><topic>Calcinosis - epidemiology</topic><topic>Calcinosis - pathology</topic><topic>Carcinoma, Intraductal, Noninfiltrating - diagnostic imaging</topic><topic>Carcinoma, Intraductal, Noninfiltrating - epidemiology</topic><topic>Carcinoma, Intraductal, Noninfiltrating - pathology</topic><topic>Chi-Square Distribution</topic><topic>Early Detection of Cancer</topic><topic>Female</topic><topic>Genital system. Mammary gland</topic><topic>Humans</topic><topic>Incidence</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Mammography - methods</topic><topic>Mass Screening</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Norway - epidemiology</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hofvind, Solveig</creatorcontrib><creatorcontrib>Iversen, Barbro F</creatorcontrib><creatorcontrib>Eriksen, Liv</creatorcontrib><creatorcontrib>Styr, Bodil M</creatorcontrib><creatorcontrib>Kjellevold, Kjell</creatorcontrib><creatorcontrib>Kurz, Kathinka D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta radiologica (1987)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hofvind, Solveig</au><au>Iversen, Barbro F</au><au>Eriksen, Liv</au><au>Styr, Bodil M</au><au>Kjellevold, Kjell</au><au>Kurz, Kathinka D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mammographic morphology and distribution of calcifications in ductal carcinoma in situ diagnosed in organized screening</atitle><jtitle>Acta radiologica (1987)</jtitle><addtitle>Acta Radiol</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>52</volume><issue>5</issue><spage>481</spage><epage>487</epage><pages>481-487</pages><issn>0284-1851</issn><eissn>1600-0455</eissn><coden>ACRAE3</coden><abstract>Background
Ductal carcinoma in situ of the breast (DCIS) represents a challenge in mammographic screening due to its unknown progression into invasive cancer. The majority of the DCIS is detected due to signs of calcifications on the mammograms.
Purpose
To analyze the combinations of mammographic morphology and distribution of calcifications by Van Nuys nuclear grade (grade).
Material and Methods
A total of 217 DCIS diagnosed in women aged 50–69 years old who participated in the Norwegian Breast Cancer Screening Program in the period November 1995 to December 2007 were reviewed by four breast imaging specialists. The mammograms were classified according to the morphology and distribution of the calcifications, using BI-RADS nomenclature. Chi square test was used to compare the groups of morphology and distribution by grade.
Results
Calcifications were identified in 93% (202/217) of the cases, 15% (30/202) as grade 1 and 74% (149/202) as grade 3. Fine pleomorphic calcifications were seen in 38% (77/202) of the lesions and fine linear and fine linear branching in 31% (62/202). Sixty-nine percent (53/77) of the fine pleomorphic and 84% (52/62) of the fine linear and fine linear branching calcifications were high grade lesions. Grouped distribution was seen in about half of all the cases (104/202). Among the high grade lesions with fine pleomorphic or fine linear and fine linear branching calcifications, 75% (40/53) and 69% (36/52), respectively, had grouped or segmental distribution.
Conclusion
DCIS presented overlapping groups of morphology and distribution of calcification by grade, but fine pleomorphic and fine linear and fine linear branching calcifications with grouped and segmental distributions were associated with high grade DCIS. Seeking for further knowledge that allows separation of non-high grade from high grade DCIS has to continue to improve the quality of mammographic screening.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>21498306</pmid><doi>10.1258/ar.2011.100357</doi><tpages>7</tpages></addata></record> |
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subjects | Aged Biological and medical sciences Breast Neoplasms - diagnostic imaging Breast Neoplasms - epidemiology Breast Neoplasms - pathology Calcinosis - diagnostic imaging Calcinosis - epidemiology Calcinosis - pathology Carcinoma, Intraductal, Noninfiltrating - diagnostic imaging Carcinoma, Intraductal, Noninfiltrating - epidemiology Carcinoma, Intraductal, Noninfiltrating - pathology Chi-Square Distribution Early Detection of Cancer Female Genital system. Mammary gland Humans Incidence Investigative techniques, diagnostic techniques (general aspects) Mammography - methods Mass Screening Medical sciences Middle Aged Norway - epidemiology Radiodiagnosis. Nmr imagery. Nmr spectrometry |
title | Mammographic morphology and distribution of calcifications in ductal carcinoma in situ diagnosed in organized screening |
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