Host Mouse Strain Is Not Selective for a Laboratory Adapted Strain of Schistosoma mansoni

We genotyped pooled adult worms of Schistosoma mansoni from infected CF1, C57BL/6, BALB/c, and BALB/c interferon gamma knockout mice in order to establish if mouse strain differences selected for parasite genotypes. We also compared differentiation in eggs collected from liver and intestines to dete...

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Bibliographic Details
Published in:The Journal of parasitology 2011-06, Vol.97 (3), p.518-521
Main Authors: Blank, Walter A, Liu, Shi Fan, Prasad, Jayendra, Blanton, Ronald E
Format: Article
Language:English
Subjects:
Animals
Antibodies, Helminth - blood
Biological and medical sciences
Biomphalaria
Cercariae
Differential distribution
DNA, Helminth
Eggs
Enzyme-Linked Immunosorbent Assay
Female
Fundamental and applied biological sciences. Psychology
Gene Frequency
General aspects
General aspects and techniques. Study of several systematic groups. Models
Genotype
Genotypes
Immunoglobulin G - blood
Infections
Interferon-gamma - genetics
Intestines - parasitology
Invertebrates
Laboratories
Liver
Liver - parasitology
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Knockout
Mollusks
Parasite hosts
Parasites
Parasitology
Population genetics
RESEARCH NOTES
Schistosoma mansoni
Schistosoma mansoni - classification
Schistosoma mansoni - genetics
Schistosoma mansoni - immunology
Schistosomiasis mansoni - immunology
Schistosomiasis mansoni - parasitology
Sex Ratio
Worms
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Description
Summary:We genotyped pooled adult worms of Schistosoma mansoni from infected CF1, C57BL/6, BALB/c, and BALB/c interferon gamma knockout mice in order to establish if mouse strain differences selected for parasite genotypes. We also compared differentiation in eggs collected from liver and intestines to determine if there was differential distribution of parasite strains in the vertebrate host that might account for any genotype selection. We found that mouse strains with differing immune responses did not differ in resistance to infection and did not select for parasite genotypes. Schistosoma mansoni egg allele frequencies were also equally distributed in tissues and the difference between adult and egg allele frequencies was negligible.
ISSN:0022-3395
1937-2345
DOI:10.1645/GE-2671.1