Flavanols from green tea and phenolic acids from coffee: Critical quantitative evaluation of the pharmacokinetic data in humans after consumption of single doses of beverages

Coffee contains a complex mixture of chlorogenic acids, which are mainly ferulic and caffeic acids ester‐linked to quinic acid. Green tea contains flavanols, mainly (−)‐epigallocatechin gallate (EGCG), (−)‐epigallocatechin (EGC) and (−)‐epicatechin (EC). For healthy humans, we identified seven studi...

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Bibliographic Details
Published in:Molecular nutrition & food research 2011-06, Vol.55 (6), p.864-873
Main Authors: Williamson, Gary, Dionisi, Fabiola, Renouf, Mathieu
Format: Article
Language:English
Subjects:
Bifidobacterium - metabolism
Bioavailability
Catechin
Cinnamates - analysis
Cinnamates - blood
Cinnamates - metabolism
Cinnamates - urine
Coffee
Coffee - chemistry
Flavonoids - analysis
Flavonoids - blood
Flavonoids - metabolism
Flavonoids - urine
Green tea
Half-Life
Humans
Hydroxybenzoates - analysis
Hydroxybenzoates - blood
Hydroxybenzoates - metabolism
Hydroxybenzoates - urine
Intestinal Absorption
Kinetics
Lactobacillus - metabolism
Pharmacokinetics
Tea - chemistry
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Summary:Coffee contains a complex mixture of chlorogenic acids, which are mainly ferulic and caffeic acids ester‐linked to quinic acid. Green tea contains flavanols, mainly (−)‐epigallocatechin gallate (EGCG), (−)‐epigallocatechin (EGC) and (−)‐epicatechin (EC). For healthy humans, we identified seven studies on green tea in liquid form and five on coffee beverage reporting single‐dose plasma pharmacokinetics. Weighted averages, based on the number of subjects, and elimination of outliers, allowed estimation of some pharmacokinetic parameters. After consumption of an “average” cup of green tea containing 112 mg of (−)‐epigallocatechin gallate, 51 mg of EGC and 15 mg of EC in 200 mL, the predicted Cmax values (total free and sulfate/glucuronide conjugates) in plasma are 125, 181 and 76 nM, respectively, together with 94 nM methyl‐EGC and 51 nM methyl‐EC (standard deviation
ISSN:1613-4125
1613-4133
DOI:10.1002/mnfr.201000631