Effects of ophthalmic disease on concentrations of plasma fibrinogen and serum amyloid A in the horse

Summary Reasons for performing study: There is little scientific information available about the ability of ocular disease to cause a systemic inflammatory response. Horses are frequently affected with ocular disease and ensuring their systemic health prior to performing vision saving surgery under...

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Bibliographic Details
Published in:Equine veterinary journal 2011-07, Vol.43 (4), p.460-465
Main Authors: LABELLE, A. L., HAMOR, R. E., MACNEILL, A. L., LASCOLA, K. M., BREAUX, C. B., TOLAR, E. L.
Format: Article
Language:English
Subjects:
acute phase proteins
Animals
eye
Eye Diseases - blood
Eye Diseases - veterinary
Female
fibrinogen
Fibrinogen - analysis
Fibrinogen - metabolism
Health risk assessment
horse
Horse Diseases - blood
Horses
Immune system
Male
Prospective Studies
Proteins
serum amyloid A
Serum Amyloid A Protein - analysis
Serum Amyloid A Protein - metabolism
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Summary:Summary Reasons for performing study: There is little scientific information available about the ability of ocular disease to cause a systemic inflammatory response. Horses are frequently affected with ocular disease and ensuring their systemic health prior to performing vision saving surgery under anaesthesia is essential for the successful treatment of ophthalmic disease. Hypothesis: Ocular disease will cause elevations in the concentration of the acute phase proteins fibrinogen and serum amyloid A in peripheral blood. Methods: Whole blood and serum samples were obtained from 38 mature horses with ulcerative keratitis or uveitis and no evidence of systemic disease, 9 mature horses with no evidence of ocular or systemic disease (negative controls) and 10 mature horses with systemic inflammatory disease and no evidence of ocular disease (positive controls). Blood samples were assayed for concentrations of the acute phase proteins fibrinogen and serum amyloid A. Results: Fibrinogen and serum amyloid A were significantly different in the positive control group compared to the negative control, corneal disease and uveitis groups (P
ISSN:0425-1644
2042-3306
DOI:10.1111/j.2042-3306.2010.00305.x