Classical and Follicular Variant Papillary Thyroid Carcinoma: Comparison of Clinical, Ultrasonographical, Cytological, and Histopathological Features in 444 Patients

Follicular variant papillary thyroid carcinoma (FVPTC) is the most common variant of papillary thyroid carcinoma (PTC) after classical PTC (CPTC). In this study, we aimed to compare functional status, ultrasonographical features, cytological results, and histopathological characteristics of patients...

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Bibliographic Details
Published in:Endocrine pathology 2011-06, Vol.22 (2), p.58-65
Main Authors: Ozdemir, Didem, Ersoy, Reyhan, Cuhaci, Neslihan, Arpaci, Dilek, Ersoy, Eren P., Korukluoglu, Birol, Guler, Gulnur, Cakir, Bekir
Format: Article
Language:English
Subjects:
Adult
Biopsy, Fine-Needle
Carcinoma
Carcinoma, Papillary
Carcinoma, Papillary, Follicular - diagnosis
Carcinoma, Papillary, Follicular - metabolism
Endocrinology
Female
Humans
Male
Medicine
Medicine & Public Health
Neoplasm Invasiveness
Oncology
Pathology
Retrospective Studies
Sex Factors
Thyroid Cancer, Papillary
Thyroid Gland - diagnostic imaging
Thyroid Gland - pathology
Thyroid Hormones - blood
Thyroid Neoplasms - diagnosis
Thyroid Neoplasms - metabolism
Ultrasonography
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Summary:Follicular variant papillary thyroid carcinoma (FVPTC) is the most common variant of papillary thyroid carcinoma (PTC) after classical PTC (CPTC). In this study, we aimed to compare functional status, ultrasonographical features, cytological results, and histopathological characteristics of patients with CPTC and FVPTC. Preoperative thyroid functions, thyroid autoantibodies, ultrasonographical features, cytology, and histopathology results of 354 (79.9%) CPTC and 90 (20.3%) FVPTC patients were reviewed retrospectively. Sex distribution, mean age, thyroid autoantibody positivity, and thyroid dysfunctions were similar in two groups. Among 320 patients with preoperative ultrasonography (US) findings, a hypoechoic halo was observed more frequently ( p  = 0.003), and marginal irregularity was observed less commonly ( p  = 0.024) in FVPTC lesions. In CPTC, rate of malignant cytology ( p  = 0.001), and in FVPTC, rate of suspicious cytology ( p  
ISSN:1046-3976
1559-0097
DOI:10.1007/s12022-011-9160-0