Propranolol for Infantile Hemangiomas

:  Propranolol has been used successfully in a limited number of children with infantile hemangiomas. This multicenter retrospective study describes the efficacy and adverse effects of propranolol in infantile hemangioma. Seventy‐one infants with infantile hemangiomas were treated with oral proprano...

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Published in:Pediatric dermatology 2011-03, Vol.28 (2), p.108-114
Main Authors: Bagazgoitia, Lorea, Torrelo, Antonio, Gutiérrez, Juan Carlos López, Hernández-Martín, Ángela, Luna, Paula, Gutiérrez, Marta, Baño, Antonio, Tamariz, Amalia, Larralde, Margarita, Alvarez, Roser, Pardo, Nuria, Baselga, Eulalia
Format: Article
Language:English
Subjects:
Administration, Oral
Adrenergic beta-Antagonists - administration & dosage
Adrenergic beta-Antagonists - adverse effects
Biological and medical sciences
Child, Preschool
Dermatology
Female
General aspects
Hemangioma - drug therapy
Humans
Infant
Male
Medical sciences
Propranolol - administration & dosage
Propranolol - adverse effects
Retrospective Studies
Severity of Illness Index
Skin Neoplasms - drug therapy
Treatment Outcome
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Summary::  Propranolol has been used successfully in a limited number of children with infantile hemangiomas. This multicenter retrospective study describes the efficacy and adverse effects of propranolol in infantile hemangioma. Seventy‐one infants with infantile hemangiomas were treated with oral propranolol, 1 mg/kg/12 hours, for at least 12 weeks. A photograph based severity scoring assessment was performed by five observers to evaluate efficacy, utilizing a scoring system of 10 as the original infantile hemangioma before treatment and 0 as completely normal skin. The mean of the five independent measurements was used in the analysis. Propranolol was a rapid and effective treatment for infantile hemangiomas at 4 weeks (p 
ISSN:0736-8046
1525-1470
DOI:10.1111/j.1525-1470.2011.01345.x