First dinuclear Re/Tc complex as a potential bimodal Optical/SPECT molecular imaging agent

In this communication, a novel synthetic pathway has been applied to prepare a dual imaging agent in a single molecule. The dinuclear Re(I)/Tc(I) complex 6, namely [Re(CO)(3)(bipy){(4-PyrIDA)Tc(CO)(3)}], is the first example of a Re/Tc-based heterometallic assembly which could act as a potential bim...

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Bibliographic Details
Published in:Dalton transactions : an international journal of inorganic chemistry 2011-06, Vol.40 (23), p.6206-6209
Main Authors: Boulay, Alexandre, Artigau, Marine, Coulais, Yvon, Picard, Claude, Mestre-Voegtlé, Béatrice, Benoist, Eric
Format: Article
Language:English
Subjects:
Assembly
Biological
Contrast Media - chemical synthesis
Contrast Media - chemistry
Coordination Complexes - chemical synthesis
Coordination Complexes - chemistry
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Imaging
Pathways
Prints
Rhenium - chemistry
Spectrophotometry, Ultraviolet
Technetium - chemistry
Tomography, Emission-Computed, Single-Photon
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Summary:In this communication, a novel synthetic pathway has been applied to prepare a dual imaging agent in a single molecule. The dinuclear Re(I)/Tc(I) complex 6, namely [Re(CO)(3)(bipy){(4-PyrIDA)Tc(CO)(3)}], is the first example of a Re/Tc-based heterometallic assembly which could act as a potential bimodal Optical/SPECT probe. Interestingly, the Re(I) complex intermediate 4 exhibits significant photophysical properties for biological applications.
ISSN:1477-9226
1477-9234
DOI:10.1039/c0dt01397h