Zinc concentrations in serum and follicular fluid during ovarian stimulation and expression of Zn2+ transporters in human oocytes and cumulus cells

Abstract Serum and follicular fluid zinc concentrations were investigated in patients undergoing assisted reproductive treatment. No correlation was found between zinc and oestradiol concentrations in serum. At the time of oocyte retrieval, zinc concentrations in follicular fluid were significantly...

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Published in:Reproductive biomedicine online 2011-06, Vol.22 (6), p.647-652
Main Authors: Ménézo, Yves, Pluntz, Laurène, Chouteau, Jacques, Gurgan, Timur, Demirol, Aygul, Dalleac, Alain, Benkhalifa, Moncef
Format: Article
Language:English
Subjects:
Carrier Proteins - biosynthesis
Cation Transport Proteins - biosynthesis
Cumulus Cells - metabolism
Estradiol - blood
Female
Follicular Fluid - chemistry
Humans
Metallothionein - biosynthesis
Obstetrics and Gynecology
Oocyte Retrieval
Oocytes - metabolism
Ovulation Induction
Pregnancy
Zinc - blood
Zinc - metabolism
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Summary:Abstract Serum and follicular fluid zinc concentrations were investigated in patients undergoing assisted reproductive treatment. No correlation was found between zinc and oestradiol concentrations in serum. At the time of oocyte retrieval, zinc concentrations in follicular fluid were significantly lower than serum concentrations ( P < 0.0001). The expression of the two families of zinc transporters, ZnT and ZiP, as well as the metal regulatory transcription factors, MTF1 and 2, and metallothioneins, which are both involved in regulatory aspects of zinc transport, was assayed in cumulus cells and in germinal-vesicle oocytes. Most of the zinc transporters, metallothioneins and metal regulatory transcription factor are expressed in oocytes and not in cumulus cells. This may indicate an important role for zinc, in particular with potential linking to genome stability during early embryonic development. In contrast, cumulus cells seem to be at the end of their life’s journey, with weak expression of transcriptional activity linked to cellular housekeeping.
ISSN:1472-6483
1472-6491
DOI:10.1016/j.rbmo.2011.03.015