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Advances in Mucoadhesion and Mucoadhesive Polymers

Mucoadhesion is the ability of materials to adhere to mucosal membranes in the human body and provide a temporary retention. This property has been widely used to develop polymeric dosage forms for buccal, oral, nasal, ocular and vaginal drug delivery. Excellent mucoadhesive properties are typical f...

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Bibliographic Details
Published in:Macromolecular bioscience 2011-06, Vol.11 (6), p.748-764
Main Author: Khutoryanskiy, Vitaliy V.
Format: Article
Language:English
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Summary:Mucoadhesion is the ability of materials to adhere to mucosal membranes in the human body and provide a temporary retention. This property has been widely used to develop polymeric dosage forms for buccal, oral, nasal, ocular and vaginal drug delivery. Excellent mucoadhesive properties are typical for hydrophilic polymers possessing charged groups and/or non‐ionic functional groups capable of forming hydrogen bonds with mucosal surfaces. This feature article considers recent advances in the study of mucoadhesion and mucoadhesive polymers. It provides an overview on the structure of mucosal membranes, properties of mucus gels and the nature of mucoadhesion. It describes the most common methods to evaluate mucoadhesive properties of various dosage forms and discusses the main classes of mucoadhesives. The ability of certain polymers to stick to mucosal tissues has been widely exploited in design of novel systems for drug delivery. This feature article describes the recent advances in the area of mucoadhesive polymers.
ISSN:1616-5187
1616-5195
1616-5195
DOI:10.1002/mabi.201000388