Zirconium-Catalyzed Multistep Reaction of Hydrazines with Alkynes: A Non-Fischer-Type Pathway to Indoles

Dominos at zirconium: A cascade of N–N and C–H scissions and C–C and C–N coupling steps in the coordination sphere of zirconium directly converts alkynes and hydrazines into indoles. The reaction pathway differs fundamentally from that of the Fischer indole synthesis.

Saved in:
Bibliographic Details
Published in:Angewandte Chemie International Edition 2011-06, Vol.50 (25), p.5757-5761
Main Authors: Gehrmann, Thorsten, Lloret Fillol, Julio, Scholl, Solveig A., Wadepohl, Hubert, Gade, Lutz H.
Format: Article
Language:English
Subjects:
Alkynes
CN coupling
homogeneous catalysis
Indoles
reaction mechanism
Zirconium
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Dominos at zirconium: A cascade of N–N and C–H scissions and C–C and C–N coupling steps in the coordination sphere of zirconium directly converts alkynes and hydrazines into indoles. The reaction pathway differs fundamentally from that of the Fischer indole synthesis.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201101070