Rabbit antithymocyte induction and dosing in deceased donor renal transplant recipients over 60 yr of age

Patel SJ, Knight RJ, Suki WN, Abdellatif A, Duhart BT, Krauss AG, Mannan S, Nezakatgoo N, Gaber AO. Rabbit antithymocyte induction and dosing in deceased donor renal transplant recipients over 60 yr of age.
Clin Transplant 2011: 25: E250–E256. © 2011 John Wiley & Sons A/S. :  Background:  Antith...

Full description

Saved in:
Bibliographic Details
Published in:Clinical transplantation 2011-05, Vol.25 (3), p.E250-E256
Main Authors: Patel, Samir J., Knight, Richard J., Suki, Wadi N., Abdellatif, Abdul, Duhart Jr, Benjamin T., Krauss, Amy G., Mannan, Saurabh, Nezakatgoo, Nosratollah, Osama Gaber, A.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Animals
antibody induction
Antilymphocyte Serum - therapeutic use
Cadaver
Creatinine - blood
Delayed Graft Function
Dose-Response Relationship, Drug
elderly
Female
Glomerular Filtration Rate
Graft Rejection - immunology
Graft Survival - immunology
Humans
Immunosuppressive Agents - therapeutic use
Immunotherapy
Kidney Function Tests
kidney transplantation
Kidney Transplantation - immunology
Kidney Transplantation - mortality
Male
Middle Aged
rabbit antithymocyte globulin
Rabbits
Remission Induction
Retrospective Studies
Survival Rate
Tissue Donors
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Patel SJ, Knight RJ, Suki WN, Abdellatif A, Duhart BT, Krauss AG, Mannan S, Nezakatgoo N, Gaber AO. Rabbit antithymocyte induction and dosing in deceased donor renal transplant recipients over 60 yr of age.
Clin Transplant 2011: 25: E250–E256. © 2011 John Wiley & Sons A/S. :  Background:  Antithymocyte globulin (rATG) is a commonly used induction agent in renal transplantation; however, data in older kidney recipients are limited. Methods:  We reviewed charts of 301 deceased donor renal transplants who received a protocol consisting of 3–7 doses of rATG and triple maintenance therapy. Outcomes of patients >60 yr of age (n = 45) were compared to those aged 18–59 yr (n = 256). Results:  Older recipients had more diabetics, were more likely to receive expanded criteria donor kidneys (p 60 received less cumulative rATG (4.6 vs. 5.1 mg/kg; p 60 group (2% vs. 16%, p 60 group at three yr was lower (80% vs. 95%; p = 0.02). Specifically, patients >60 with delayed graft function and rATG cumulative dosing >6 mg/kg had a survival of 6 mg/kg. These data suggest that when used, lower cumulative dosages of rATG are preferable in the older recipient.
ISSN:0902-0063
1399-0012
DOI:10.1111/j.1399-0012.2010.01393.x