Reverse Remodeling and the Risk of Ventricular Tachyarrhythmias in the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial–Cardiac Resynchronization Therapy)

• Published in: Journal of the American College of Cardiology 2011-06, Vol.57 (24), p.2416-2423
• Main Authors: Barsheshet, Alon, MD, Wang, Paul J., MD, Moss, Arthur J., MD, Solomon, Scott D., MD, Al-Ahmad, Amin, MD, McNitt, Scott, MS, Foster, Elyse, MD, Huang, David T., MD, Klein, Helmut U., MD, Zareba, Wojciech, MD, PhD, Eldar, Michael, MD, Goldenberg, Ilan, MD
• Format: Article
• Language: English
• Subjects: Age Distribution; Aged; Biological and medical sciences; Cardiac arrhythmia; cardiac resynchronization therapy; Cardiac Resynchronization Therapy - adverse effects; Cardiac Resynchronization Therapy - methods; Cardiology; Cardiology. Vascular system; Cardiovascular; Confidence intervals; Defibrillators, Implantable - adverse effects; Drug therapy; Echocardiography, Doppler; Electrocardiography; Female; Heart attacks; heart failure; Humans; implantable cardioverter-defibrillator; Incidence; Internal Medicine; Laboratories; Male; Medical sciences; Methods; Middle Aged; Mortality; Multivariate analysis; Nitrogen; Prognosis; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Recurrence; reverse remodeling; Risk Assessment; Severity of Illness Index; Sex Distribution; Statistics, Nonparametric; Studies; Survival Analysis; Tachycardia, Ventricular - diagnostic imaging; Tachycardia, Ventricular - mortality; Tachycardia, Ventricular - therapy; Treatment Outcome; Ultrasonic imaging; ventricular arrhythmia; Ventricular Fibrillation - diagnostic imaging; Ventricular Fibrillation - mortality; Ventricular Fibrillation - therapy; Ventricular Remodeling
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2010.12.041

Objectives We aimed to evaluate the relationship between echocardiographic response to cardiac resynchronization therapy (CRT) and the risk of subsequent ventricular tachyarrhythmias (VTAs). Background Current data regarding the effect of CRT on the risk of VTA are limited and conflicting. Methods The risk of a first appropriate implantable cardioverter-defibrillator (ICD) therapy for VTA (including ventricular tachycardia, ventricular fibrillation, and ventricular flutter) was compared between high- and low-echocardiographic responders to CRT defibrillator (CRT-D) therapy (defined as ≥25% and