Effect of resistance training during hemodialysis on circulating cytokines: a randomized controlled trial

• Published in: European journal of applied physiology 2011-07, Vol.111 (7), p.1437-1445
• Main Authors: Cheema, Birinder Singh Bobby, Abas, Haifa, Smith, Benjamin C. F., O’Sullivan, Anthony J., Chan, Maria, Patwardhan, Aditi, Kelly, John, Gillin, Adrian, Pang, Glen, Lloyd, Brad, Berger, Klaus, Baune, Bernhard T., Fiatarone Singh, Maria A.
• Format: Article
• Language: English
• Subjects: Adipose tissue; Aged; Algorithms; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Body composition; Chronic illnesses; Clinical trials; Cytokines; Cytokines - blood; Cytokines - metabolism; Exercise - physiology; Exercise Therapy; Female; Fundamental and applied biological sciences. Psychology; Hemodialysis; Hospitals; Human Physiology; Humans; Kidney diseases; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - metabolism; Kidney Failure, Chronic - physiopathology; Kidney Failure, Chronic - therapy; Male; Medicine; Middle Aged; Muscle, Skeletal - metabolism; Muscle, Skeletal - physiology; Nutrition; Occupational Medicine/Industrial Medicine; Original Article; Quality of life; Renal Dialysis; Resistance Training; Sports Medicine; Strength training; Treatment Outcome; Tumor necrosis factor-TNF; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports; Weight control
• ISSN: 1439-6319; 1439-6327
• DOI: 10.1007/s00421-010-1763-5

The purpose of this study was to evaluate the effect of a 12-week intradialytic progressive resistance training (PRT) regimen on circulating pro- and anti-inflammatory cytokines. Forty-nine patients (62.6 ± 14.2 years) were recruited from the outpatient hemodialysis unit of the St. George Public Hospital, Sydney, Australia. Patients were randomized to: PRT + usual care ( n  = 24) or usual care control ( n  = 25). The PRT group performed two sets of 10 exercises at high intensity using free-weights, 3 times per week for 12 weeks during dialysis, while the control group did not exercise. Tumor necrosis factor-alpha, interleukin-1b, interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10, and interleukin-12 were measured in serum before and after the intervention period. Muscle cross-sectional area (CSA), intramuscular lipid, intermuscular adipose tissue, and subcutaneous and total thigh fat, evaluated via computed tomography of the non-dominant mid-thigh, were also collected at both time points. All cytokines were significantly elevated in the total cohort at baseline compared with normative data. There were no cytokine changes over time or between groups ( p  > 0.05). In secondary analyses pooling the groups, changes in logIL-6 and IL-8 were inversely related to changes subcutaneous thigh fat ( p