[Glu2 ]TRH dose-dependently attenuates TRH-evoked analeptic effect in mice

Abstract Thyrotropin-releasing hormone (TRH, pGlu-His-Pro-NH2 ) and the structurally related [Glu2 ]TRH (pGlu-Glu-Pro-NH2 ) are endogenous peptides with a plethora of actions in the central nervous system. Many centrally-mediated effects of TRH are shared with those of [Glu2 ]TRH, although the invol...

Full description

Saved in:
Bibliographic Details
Published in:Brain research bulletin 2010-04, Vol.82 (1), p.83-86
Main Authors: Nguyen, Vien, Zharikova, Alevtina D, Prokai-Tatrai, Katalin, Prokai, Laszlo
Format: Article
Language:English
Subjects:
Acetylcholine
Analeptic effect
Animals
Central Nervous System Stimulants - chemistry
Central Nervous System Stimulants - pharmacology
Dose-Response Relationship, Drug
Endogenous analogue
Hypnotics and Sedatives - pharmacology
Mice
Molecular Structure
Neurology
Pentobarbital - pharmacology
Sleep - drug effects
Thyrotropin-releasing hormone
Thyrotropin-Releasing Hormone - analogs & derivatives
Thyrotropin-Releasing Hormone - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Thyrotropin-releasing hormone (TRH, pGlu-His-Pro-NH2 ) and the structurally related [Glu2 ]TRH (pGlu-Glu-Pro-NH2 ) are endogenous peptides with a plethora of actions in the central nervous system. Many centrally-mediated effects of TRH are shared with those of [Glu2 ]TRH, although the involvement of different receptors is presumed. The analeptic action is the best-known TRH-related central nervous system effect. While [Glu2 ]TRH itself is analeptic, its co-administration with TRH into mice produced a dose-dependent attenuation of TRH-evoked reversal of barbiturate-induced sleeping time. This finding is in agreement with our previous observations that [Glu2 ]TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. Taken together, [Glu2 ]TRH may be considered as a negative modulator for the cholinergic effect of TRH in the mouse brain.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2010.02.007