Evaluation of Molecular Assays for Rapid Detection of Methicillin-Resistant Staphylococcus aureus

The diagnostic sensitivities of the BD GeneOhm and Cepheid Xpert assays were compared using culture on log-serial dilutions of well-characterized methicillin-resistant Staphylococcus aureus (MRSA) and non-MRSA strains and on nasal and groin swabs from patients with histories of MRSA carriage. The se...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2010-12, Vol.48 (12), p.4598-4601
Main Authors: Malhotra-Kumar, Surbhi, Van Heirstraeten, Liesbet, Lee, Andie, Abrahantes, José Cortinas, Lammens, Christine, Vanhommerig, Evelyn, Molenberghs, Geert, Aerts, Marc, Harbarth, Stephan, Goossens, Herman
Format: Article
Language:English
Subjects:
Bacteriological Techniques - methods
Bacteriology
Biological and medical sciences
Carrier State - diagnosis
Carrier State - microbiology
Coagulase - genetics
Fundamental and applied biological sciences. Psychology
Groin - microbiology
Humans
Methicillin-Resistant Staphylococcus aureus - isolation & purification
Microbiology
Miscellaneous
Molecular Diagnostic Techniques - methods
Nasal Mucosa - microbiology
Sensitivity and Specificity
Staphylococcal Infections - diagnosis
Staphylococcal Infections - microbiology
Staphylococcus aureus
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Summary:The diagnostic sensitivities of the BD GeneOhm and Cepheid Xpert assays were compared using culture on log-serial dilutions of well-characterized methicillin-resistant Staphylococcus aureus (MRSA) and non-MRSA strains and on nasal and groin swabs from patients with histories of MRSA carriage. The sensitivities of GeneOhm and Xpert were high at 10³-CFU/ml MRSA concentrations (92.3% and 96.3%, respectively) although decreased considerably (
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.00004-10