Discordance rates between Trofile registered test and short-term virological response to maraviroc

Enhanced sensitivity Trofile registered (ES-Trofile registered ) is the most frequently used technique to assay HIV tropism. A clinical approach to predict CCR5-antagonists efficacy, based on the virological response to a short-term maraviroc exposure (Maraviroc Clinical Test, MCT), has been recentl...

Full description

Saved in:
Bibliographic Details
Published in:Antiviral research 2011-02, Vol.89 (2), p.182-185
Main Authors: Genebat, Miguel, Ruiz-Mateos, Ezequiel, Gonzalez-Serna, Alejandro, Pulido, Ildefonso, Munoz-Fernandez, M super (a) Angeles, Ferrando-Martinez, Sara, Leal, Manuel
Format: Article
Language:English
Subjects:
Human immunodeficiency virus
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Enhanced sensitivity Trofile registered (ES-Trofile registered ) is the most frequently used technique to assay HIV tropism. A clinical approach to predict CCR5-antagonists efficacy, based on the virological response to a short-term maraviroc exposure (Maraviroc Clinical Test, MCT), has been recently reported. We compared the results of ES-Trofile registered with MCT in 47 HIV-infected patients, and a global discordance around 15% was observed between the phenotypic method and the clinical approach. Discordance results were mainly found in patients with an ES-Trofile registered reported as dual/mixed. These provocative results might have important clinical implications and should be considered in order to accurately prescribe treatment with CCR5 antagonists.
ISSN:0166-3542
DOI:10.1016/j.antiviral.2010.11.015