Induction of cytotoxicity by photoexcitation of TiO sub(2) can prolong survival in glioma-bearing mice

We have investigated the possibility that photoexcited titanium dioxide (TiO sub(2)) could inhibit the growth of malignant cells. We studied the anti-glioma effects of nano-TiO sub(2) excited with ultraviolet A (UVA) irradiation both in vitro and in vivo. Transmission electron microscopy demonstrate...

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Bibliographic Details
Published in:Molecular biology reports 2011-01, Vol.38 (1), p.523-530
Main Authors: Wang, Chao, Cao, Shouqiang, Tie, Xinxin, Qiu, Bo, Wu, Anhua, Zheng, Zhihong
Format: Article
Language:English
Subjects:
Antitumor activity
Apoptosis
Bcl-2 protein
Brain tumors
Cell proliferation
Cytotoxicity
Glioma
Glioma cells
Necrosis
Phagocytosis
photodynamic therapy
Polymerase chain reaction
Survival
Titanium dioxide
Transmission electron microscopy
Tumors
U.V. radiation
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Summary:We have investigated the possibility that photoexcited titanium dioxide (TiO sub(2)) could inhibit the growth of malignant cells. We studied the anti-glioma effects of nano-TiO sub(2) excited with ultraviolet A (UVA) irradiation both in vitro and in vivo. Transmission electron microscopy demonstrated that glioma cells take up TiO sub(2) by phagocytosis, and vital staining revealed that TiO sub(2) alone has no effect on glioma cell proliferation. However, if TiO sub(2) was combined with UVA irradiation the proliferation rate was decreased significantly compared to controls (P
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-010-0136-9