Immunohistochemical Detection of Raf Kinase Inhibitor Protein in Normal Cervical Tissue and Cervical Cancer Tissue

Raf kinase inhibitor protein (RKIP) may be a suppressor of metastasis: RKIP levels are high in normal tissues, low in primary cancers and lowest or absent in metastatic cancers. This immunohisto chemistry study investigated RKIP protein levels in 250 clinical specimens of human cervical tissue and l...

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Bibliographic Details
Published in:Journal of international medical research 2011-02, Vol.39 (1), p.229-237
Main Authors: Hu, CJ, Zhou, L, Zhang, J, Huang, C, Zhang, GM
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Cervical Intraepithelial Neoplasia - genetics
Cervical Intraepithelial Neoplasia - metabolism
Cervical Intraepithelial Neoplasia - pathology
Cervix Uteri - metabolism
Cervix Uteri - pathology
Down-Regulation
Female
Formaldehyde
Humans
Immunohistochemistry
Lymphatic Metastasis - genetics
Lymphatic Metastasis - pathology
Neoplasm Staging
Paraffin Embedding
Phosphatidylethanolamine Binding Protein - genetics
Phosphatidylethanolamine Binding Protein - metabolism
Tissue Fixation
Uterine Cervical Neoplasms - genetics
Uterine Cervical Neoplasms - metabolism
Uterine Cervical Neoplasms - pathology
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Summary:Raf kinase inhibitor protein (RKIP) may be a suppressor of metastasis: RKIP levels are high in normal tissues, low in primary cancers and lowest or absent in metastatic cancers. This immunohisto chemistry study investigated RKIP protein levels in 250 clinical specimens of human cervical tissue and lymph node metastases (LNM) from 210 patients with normal cervical tissue, cervical intra-epithelial neoplasia (CIN), or cervical cancer with/without LNM. Thirty-nine (86.7%) of the 45 normal-tissue samples were RKIP-positive, six (13.3%) were RKIP-negative; 48/60 (80.0%) CIN samples were positive, 12 (20.0%) were negative; 47/105 (44.8%) cervical cancer tissue samples were positive, 58 (55.2%) were negative; only 7/40 (17.5%) LNM tissue samples were positive, 33 (82.5%) were negative. There was no significant correlation between RKIP positivity and clinical stage, microscopic subtype or pathological differentiation grade. RKIP positivity correlated inversely with LNM. RKIP may play a role in cervical-cancer genesis and metastasis; RKIP down-regulation was associated with metastatic disease in human cervical cancer.
ISSN:0300-0605
1473-2300
DOI:10.1177/147323001103900125