Analysis of Composition, Molecular Weight, and Water Content Variations in Sodium Alginate Using Solid-State NMR Spectroscopy

Solid‐state nuclear magnetic resonance (SSNMR) spectroscopy has become more prevalent in the pharmaceutical industry due to its nondestructive nature and the wealth of information it can provide on a wide variety of solid samples. In this study, SSNMR spectra and relaxation times were used to analyz...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pharmaceutical sciences 2011-08, Vol.100 (8), p.3441-3452
Main Authors: Sperger, Diana M., Fu, Shao, Block, Lawrence H., Munson, Eric J.
Format: Article
Language:English
Subjects:
alginate
Alginates - chemistry
Biological and medical sciences
Calcium - analysis
Carbohydrate Conformation
Carbohydrate Sequence
excipients
Excipients - chemistry
General pharmacology
Glucuronic Acid - chemistry
Hexuronic Acids - chemistry
hydration
Magnetic Resonance Spectroscopy
Medical sciences
mobility
Molecular Weight
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Phase Transition
polymers
relaxation time
solid-state NMR
structure
Tablets
Technology, Pharmaceutical - methods
Technology, Pharmaceutical - standards
Thermogravimetry
Viscosity
Water - analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Solid‐state nuclear magnetic resonance (SSNMR) spectroscopy has become more prevalent in the pharmaceutical industry due to its nondestructive nature and the wealth of information it can provide on a wide variety of solid samples. In this study, SSNMR spectra and relaxation times were used to analyze differences in monomer composition, molecular weight (MW), and water content among various sodium alginate samples. Differences in structure could be determined via spectral deconvolution of SSNMR spectra, and differences in intrinsic viscosity, MW, and water content were found to correlate to SSNMR relaxation times. The technique was found to be selective and sensitive enough to detect these changes in sodium alginate even when diluted with another excipient and compressed into a tablet. © 2011 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 100:3441–3452, 2011
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.22559