Revolution through Genomics in Investigative and Discovery Toxicology

The remarkable technologic and methodologic advances spurred on by the Human Genome Project are being applied throughout the life sciences. In the field of toxicology, high-resolution assays now make it possible to discover virtually all the differences in gene expression brought on by exposure to a...

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Bibliographic Details
Published in:Toxicologic pathology 1999-01, Vol.27 (1), p.107-110
Main Authors: Rodi, Charles P., Bunch, Roderick T., Curtiss, Sandra W., Kier, Larry D., Cabonce, Marc A., Davila, Julio C., Mitchell, Michael D., Alden, Carl L., Morris, Dale L.
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Biological and medical sciences
Gene Expression Regulation - drug effects
General aspects
Genetic Techniques
Genome, Human
Humans
Medical sciences
Pharmacology. Drug treatments
Toxicology
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Summary:The remarkable technologic and methodologic advances spurred on by the Human Genome Project are being applied throughout the life sciences. In the field of toxicology, high-resolution assays now make it possible to discover virtually all the differences in gene expression brought on by exposure to a particular xenobiotic. There are 2 principal approaches used to build a catalog of changes in gene expression: hybridization microarrays and gel-based methods, such as differential display and AFLP™-based mRNA fingerprinting. The power of such approaches is exemplified by the identification of more than 300 genes that differ in expression level by at least 2-fold in response to the nongenotoxic rodent liver carcinogen phenobarbital.
ISSN:0192-6233
1533-1601
DOI:10.1177/019262339902700120