Interleukin-2 −330T>G Genetic Polymorphism Associates with Prognosis Following Surgery for Thoracic Esophageal Squamous Cell Cancer

• Published in: Annals of surgical oncology 2011-07, Vol.18 (7), p.1995-2002
• Main Authors: Motoyama, Satoru, Miura, Masatomo, Hinai, Yudai, Maruyama, Kiyotomi, Usami, Shuetsu, Yoshino, Kei, Nakatsu, Toshinobu, Saito, Hajime, Minamiya, Yoshihiro, Ogawa, Jun-ichi
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - secondary; Carcinoma, Squamous Cell - surgery; DNA, Neoplasm - blood; DNA, Neoplasm - genetics; Esophageal Neoplasms - genetics; Esophageal Neoplasms - pathology; Esophageal Neoplasms - surgery; Esophagectomy; Female; Follow-Up Studies; Gastrointestinal Oncology; Humans; Interferon-gamma - genetics; Interleukin-10 - genetics; Interleukin-2 - genetics; Interleukin-4 - genetics; Lymphatic Metastasis; Male; Medicine; Medicine & Public Health; Middle Aged; Oncology; Polymerase Chain Reaction; Polymorphism, Genetic - genetics; Prognosis; Surgery; Surgical Oncology; Survival Rate; Th1 Cells; Th2 Cells; Thoracic Neoplasms - genetics; Thoracic Neoplasms - pathology; Thoracic Neoplasms - surgery; Treatment Outcome
• ISSN: 1068-9265; 1534-4681
• DOI: 10.1245/s10434-011-1553-2

Background Key molecules in the T helper (Th)1 and Th2 pathways underlie differential responses to the progression and surgical treatment of cancer. We investigated the relationship between Th1/Th2 cytokine polymorphism and prognosis in patients with thoracic esophageal squamous cell cancer. Materials and Methods The study participants were 159 Japanese patients treated for thoracic esophageal squamous cell cancer with curative esophagectomy at Akita University Hospital. We determined the associations between prognosis following esophagectomy and genetic polymorphisms in Th1 cytokines (interleukin [IL]-2, Interferon-γ, IL-12β), and Th2 cytokines (IL-4, IL-10). Results IL-2 −330T>G genetic polymorphism was significantly associated with prognosis after esophagectomy. Univariate and multivariate analyses using a Cox proportional hazards model revealed that patients carrying the IL-2 −330G/G genotype had a significantly poorer prognosis than those carrying the T/G or T/T genotype. However, IL-2 −330T>G polymorphism was not associated with preoperative serum IL-2 levels. Moreover, interferon-γ, IL-12β, IL-4, and IL-10 genetic polymorphisms were not associated with prognosis after esophagectomy for thoracic esophageal squamous cell cancer. Conclusions It is suggested that IL-2 −330T>G genetic polymorphism may be a predictive factor for prognosis in patients receiving esophagectomy for thoracic esophageal squamous cell cancer.