Primary intestinal lymphoma in patients with inflammatory bowel disease: A descriptive series from the prebiologic therapy era

• Published in: Inflammatory bowel diseases 2011-07, Vol.17 (7), p.1557-1563
• Main Authors: Holubar, Stefan D., Dozois, Eric J., Loftus, Edward V., Teh, Swee H., Benavente, Luis A., Harmsen, W. Scott, Wolff, Bruce G., Cima, Robert R., Larson, David W.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age; Aged; Aged, 80 and over; biologic therapy; Biological Therapy; Chemotherapy; Crohn's disease; Data processing; Diarrhea; Duodenum; Female; gastrointestinal carcinogenesis; Humans; inflammatory bowel disease; Inflammatory bowel diseases; Inflammatory Bowel Diseases - complications; Inflammatory Bowel Diseases - mortality; Inflammatory Bowel Diseases - therapy; infliximab; Intestinal Neoplasms - etiology; Intestinal Neoplasms - mortality; Intestinal Neoplasms - therapy; Intestine; Lymphoma; Lymphoma, B-Cell - etiology; Lymphoma, B-Cell - mortality; Lymphoma, B-Cell - therapy; Male; Middle Aged; Radiation; Retrospective Studies; Stomach; Surgery; surgery lymphoma; Survival; Survival Rate; Treatment Outcome; ulcerative colitis; Young Adult
• ISSN: 1078-0998; 1536-4844; 1536-4844
• DOI: 10.1002/ibd.21516

Background: Primary intestinal lymphoma in the setting of inflammatory bowel disease (IBD) is uncommon and may be associated with immune suppressive therapy. We report clinical features and outcomes in patients with both conditions prior to use of biologic therapy. Methods: All patients with primary intestinal lymphoma and IBD at our institution from 1960–2000 were retrospectively identified. Data reported are frequency (proportion) or median (interquartile range). Kaplan–Meier analysis was performed. Results: Fifteen patients were identified: 14 (93%) were male, 10 (66%) had Crohn's disease. Median age at diagnosis of IBD and lymphoma was 30 (22–51) and 47 (28–68) years, respectively, with bloody diarrhea the most common presenting symptom for each diagnosis. Lymphoma location was colorectal in nine (60%), small bowel in four (27%), and one (6.25%) each: stomach, duodenum, and ileal pouch. Treatments were surgery plus chemotherapy (n = 6), surgery alone (n = 3), chemotherapy alone (n = 2), chemotherapy and radiation (n = 1), surgery and radiation (n = 1); two patients died before treatment. Most patients (n = 11, 73%) were Ann Arbor stages I or II. Large cell B‐type histology was most common (n = 9, 60%). Three patients died within 30 days of lymphoma diagnosis. Survival free of death from lymphoma at 1‐ and 5‐years was 78% and 63%, respectively, and was associated with advanced lymphoma stage (P = 0.004). Conclusions: Diagnosis and treatment of primary intestinal lymphoma in patients with IBD can be challenging and requires a high index of suspicion. Optimal survival requires multimodality therapy.(Inflamm Bowel Dis 2010;)