Lessons Learned From the Systematic Evaluation of Cutaneous T-Cell Lymphomas at the National Cancer Institute and the Roadmap for Future Studies

Mycosis fungoides (MF) and Sezary syndrome (SS) are the major types of T-cell lymphomas that arise in the skin. Mycosis fungoides was first described by Alibert in 1806, super(1) and the cutaneous manifestations of plaques, tumors, and generalized erythroderma were well described by early 1900s. sup...

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Bibliographic Details
Published in:Clinical lymphoma, myeloma and leukemia myeloma and leukemia, 2010-09, Vol.10, p.S74-S79
Main Authors: Bunn, Paul A, Pacheco, Theresa
Format: Article
Language:English
Subjects:
Hematology, Oncology and Palliative Medicine
HTLV-1
Humans
Lymphoma, B-Cell
Lymphoma, T-Cell, Cutaneous
Monoclonal antibodies
Mycosis fungoides
National Cancer Institute (U.S.)
Skin Neoplasms
Sézary syndrome
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Summary:Mycosis fungoides (MF) and Sezary syndrome (SS) are the major types of T-cell lymphomas that arise in the skin. Mycosis fungoides was first described by Alibert in 1806, super(1) and the cutaneous manifestations of plaques, tumors, and generalized erythroderma were well described by early 1900s. super(2) Sezary syndrome, first described by Sezary in 1938, is characterized by generalized crythroderma and circulating arypical lymphocytes that have the same convoluted nuclei in the blood as in the skin. super(3,4) After Crossen et al demonstrated that Sezary cell and mycosis cells were lymphocytes, super(5) monoclonal antibodies (MoAbs) to lymphocyte antigens showed that they arise from the T helper subset of T lymphocytes super(6,7).
ISSN:2152-2650
2152-2669
DOI:10.3816/CLML.2010.s.012