Effect of antiretroviral drugs on the quality of semen

• Published in: Journal of medical virology 2011-08, Vol.83 (8), p.1391-1394
• Main Authors: Lambert-Niclot, Sidonie, Poirot, Catherine, Tubiana, Roland, Houssaini, Allal, Soulié, Cathia, Dominguez, Stéphanie, Schubert, Benoit, Prades, Marie, Bonmarchand, Manuela, Calvez, Vincent, Flandre, Philippe, Peytavin, Gilles, Marcelin, Anne-Geneviève
• Format: Article
• Language: English
• Subjects: Adult; Anti-HIV Agents - administration & dosage; Anti-HIV Agents - adverse effects; antiretrovirals drugs; Biological and medical sciences; Cross-Sectional Studies; Fundamental and applied biological sciences. Psychology; HIV Infections - drug therapy; HIV Infections - virology; HIV-1 - isolation & purification; Human viral diseases; Humans; Infectious diseases; Locomotion - drug effects; Male; Medical sciences; Microbiology; Miscellaneous; penetration score; Retrospective Studies; Semen - drug effects; Semen - physiology; semen quality; Spermatozoa - drug effects; Spermatozoa - physiology; Viral diseases; Virology
• ISSN: 0146-6615; 1096-9071
• DOI: 10.1002/jmv.22119

The aim of this cross‐sectional study was to determine which antiretroviral drugs (ARVs) are associated with changes in the characteristics of semen and the impact of these ARVs according to their score penetration into the male genital compartment. Data from 144 men infected with HIV‐1 enrolled in an Assisted Reproductive Technology program were analyzed retrospectively. A seminal penetration score of ARV was based on the available literature. The nonparametric Kruskal–Wallis test and chi‐square test were used. There was no difference on sperm parameters between NRTI, NNRTI, or PI regimen. In patients receiving NRTIs or PIs no differences were observed between antiretrovirals of these classes. However, in patients receiving NNRTIs, nevirapine (n = 22) was associated with a higher percentage of progressively motile spermatozoa (P