Determination of parabens in cosmetic products by solid-phase microextraction of poly(ethylene glycol) diacrylate thin film on fibers and ultra high-speed liquid chromatography with diode array detector

• Published in: Journal of separation science 2011-07, Vol.34 (13), p.1599-1606
• Main Authors: Fei, Ting, Li, Haifang, Ding, Mingyu, Ito, Masahito, Lin, Jin-Ming
• Format: Article
• Language: English
• Subjects: Analytical chemistry; Applied sciences; Arrays; Chemical industry and chemicals; Chemistry; Chromatographic methods and physical methods associated with chromatography; Chromatography, High Pressure Liquid - instrumentation; Chromatography, High Pressure Liquid - methods; coatings; Cosmetics; Cosmetics - chemistry; Cosmetics, toiletries; detection limit; Detectors; Diodes; ethylene glycol; Exact sciences and technology; Extraction; Fibers; Glycols; Liquid chromatography; methylparaben; microextraction; Other chromatographic methods; Parabens; Parabens - analysis; Parabens - isolation & purification; Poly(ethylene glycol) diacrylate; Polyethylene Glycols - chemistry; polymerization; Solid Phase Microextraction - instrumentation; Solid Phase Microextraction - methods; Solid-phase microextraction; surface area; Thin films; Ultra high-speed liquid chromatography; Washing products. Cosmetics and toiletries. Perfumes
• ISSN: 1615-9306; 1615-9314; 1615-9314
• DOI: 10.1002/jssc.201100225

The fabrication of a solid-phase microextraction (SPME) fiber through UV-induced polymerization of poly(ethylene glycol) diacrylate (PEG-DA) for determination of parabens in cosmetic products is presented in this work. The PEG-DA polymer coating was covalently attached to the fiber by introducing a surface modification with 3-(trichlorosilyl)propyl methacrylate (TPM). The PEG-DA polymer thin film coated on the fiber was homogeneous and wrinkled, which led to an increase of the surface area and high extraction efficiency. The extraction performances of the prepared SPME fibers were assessed by preconcentration of parabens including methylparaben, ethylparaben, propylparaben and benzylparaben from cosmetic products. The analysis was performed on an ultra high-speed liquid chromatography with diode array detector. The prepared SPME fibers exhibited good repeatability (for one fiber) and reproducibility (fiber-to-fiber) with RSDs of 5.4 and 6.9%, respectively. The optimized SPME method supported a wide linear range of 0.50-160 μg/mL and the detection limits for parabens were in the range of 0.12-0.15 μg/mL (S/N=3). The developed method was successfully applied for determination of parabens in cosmetic products with different natures.