The role of lymph node dissection in the management of prostate cancer

Lymph node dissection is a standard procedure for treatment of several cancers, but its role in prostate cancer (PCa) as an adjunct of radical prostatectomy is still debated and controversial. Pelvic lymph node dissection (PLND) is currently the most reliable means of diagnosis of lymph node metasta...

Full description

Saved in:
Bibliographic Details
Published in:International journal of clinical oncology 2011-06, Vol.16 (3), p.195-202
Main Authors: Miki, Jun, Egawa, Shin
Format: Article
Language:English
Subjects:
Cancer Research
Carcinoma, Renal Cell - pathology
Carcinoma, Renal Cell - secondary
Carcinoma, Renal Cell - surgery
Dissection
Humans
Lymph Node Excision - methods
Lymph Nodes - pathology
Lymph Nodes - surgery
Lymphatic Metastasis
Lymphatic system
Male
Medical procedures
Medicine
Medicine & Public Health
Neoplasm Staging
Nomograms
Oncology
Prospective Studies
Prostate cancer
Prostatectomy - methods
Prostatic Neoplasms - pathology
Prostatic Neoplasms - surgery
Review Article
Surgical Oncology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Lymph node dissection is a standard procedure for treatment of several cancers, but its role in prostate cancer (PCa) as an adjunct of radical prostatectomy is still debated and controversial. Pelvic lymph node dissection (PLND) is currently the most reliable means of diagnosis of lymph node metastases. A uniform PLND surgical template cannot be determined, but recent evidence shows that extended PLND provides more lymph nodes, increases the accuracy of detection of lymph node metastases, and affects decision making with regard to adjuvant therapy. Several nomograms have been developed to predict those who may need more extensive PLND, while sparing the rest. Importantly, no prospective data indicate that extension of PLND improves cancer control or benefits survival. A well designed prospective randomized study is needed to resolve these issues. We present a comprehensive literature review and critical discussion of the diagnostic and therapeutic role of PLND in PCa.
ISSN:1341-9625
1437-7772
DOI:10.1007/s10147-011-0245-z