Polymorphic CAG repeat numbers in the androgen receptor gene of female pattern hair loss patients

Female pattern hair loss (FPHL) is frequently referred to as female androgenetic alopecia (FAGA). However, the role of androgen in this type of hair loss remains uncertain. We previously reported greater therapeutic efficacy of finasteride in Japanese male androgenetic alopecia (MAGA) patients in ca...

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Bibliographic Details
Published in:Journal of dermatology 2011-07, Vol.38 (7), p.680-684
Main Authors: YAMAZAKI, Masashi, SATO, Akio, TOYOSHIMA, Koh-ei, KOJIMA, Yuha, OKADA, Taro, ISHII, Yoshinori, KURATA, Sotaro, YOSHIZATO, Katsutoshi, TSUBOI, Ryoji
Format: Article
Language:English
Subjects:
5-alpha Reductase Inhibitors - therapeutic use
Adult
Aged
Alopecia
Alopecia - drug therapy
Alopecia - genetics
Alopecia - pathology
androgen receptor
Androgen receptors
androgenetic alopecia
Androgens
Asian Continental Ancestry Group - genetics
Base Sequence
CAG repeats
Chromosomes, Human, X - genetics
DNA Primers - genetics
Female
female pattern hair loss
finasteride
Finasteride - therapeutic use
Hair
Humans
Male
Middle Aged
Minisatellite Repeats
Polymorphism, Genetic
Receptors, Androgen - genetics
Statistics
Treatment Outcome
Trinucleotide Repeats
X-chromosome inactivation
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Summary:Female pattern hair loss (FPHL) is frequently referred to as female androgenetic alopecia (FAGA). However, the role of androgen in this type of hair loss remains uncertain. We previously reported greater therapeutic efficacy of finasteride in Japanese male androgenetic alopecia (MAGA) patients in cases where the CAG repeats of the androgen receptor (AR) gene were short. To examine the correlation between CAG repeat numbers and the therapeutic efficacy of finasteride in FPHL patients, the efficacy of finasteride (1 mg/day) was evaluated macroscopically. Because women have two X‐chromosomes, the shorter and longer CAG repeat numbers were analyzed in 37 Japanese FPHL patients, then the correlation of these factors was statistically analyzed by anova. No statistical significance in terms of the differences in CAG repeat numbers was detected among the four groups classified on the basis of the efficacy of finasteride. From these results, it may be concluded that the efficacy of this medicine in each FPHL patient cannot be predicted by the CAG repeat numbers in the AR gene.
ISSN:0385-2407
1346-8138
DOI:10.1111/j.1346-8138.2010.01060.x