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Glycyrrhiza glabra (Linn.) and Lavandula officinalis (L.) cell suspension cultures-based biotransformation of β-artemether
The biotransformation of β-artemether ( 1 ) by cell suspension cultures of Glycyrrhiza glabra and Lavandula officinalis is reported here for the first time. The major biotransformed product appeared as a grayish-blue color spot on thin-layer chromatography (TLC) with transparent crystal-like texture...
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| Published in: | Journal of natural medicines 2011-07, Vol.65 (3-4), p.646-650 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c367t-bfffe53c75899f5486f28bfd5f8a75a6a10ca965c15a5517fd76c33d0dc995d13 |
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| cites | cdi_FETCH-LOGICAL-c367t-bfffe53c75899f5486f28bfd5f8a75a6a10ca965c15a5517fd76c33d0dc995d13 |
| container_end_page | 650 |
| container_issue | 3-4 |
| container_start_page | 646 |
| container_title | Journal of natural medicines |
| container_volume | 65 |
| creator | Patel, Suman Gaur, Rashmi Upadhyaya, Mohita Mathur, Archana Mathur, Ajay K. Bhakuni, Rajendra S. |
| description | The biotransformation of β-artemether (
1
) by cell suspension cultures of
Glycyrrhiza glabra
and
Lavandula officinalis
is reported here for the first time. The major biotransformed product appeared as a grayish-blue color spot on thin-layer chromatography (TLC) with transparent crystal-like texture. Based on its infrared (IR) and
1
H nuclear magnetic resonance (NMR) spectra, the product was characterized as a tetrahydrofuran (THF)–acetate derivative (
2
). The highest conversion efficiencies of 57 and 60% were obtained when 8–9-day-old cell suspensions of
G. glabra
and
L. officinalis
were respectively fed with 4–7 mg of compound
1
in 40 ml of medium per culture and the cells were harvested after 2–5 days of incubation. The addition of compound
1
at the beginning of the culture cycle caused severe growth depression in a dose-dependent manner, resulting in poor bioconversion efficiency of ~25% at 2–5 mg/culture dose only. |
| doi_str_mv | 10.1007/s11418-011-0539-5 |
| format | article |
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1
) by cell suspension cultures of
Glycyrrhiza glabra
and
Lavandula officinalis
is reported here for the first time. The major biotransformed product appeared as a grayish-blue color spot on thin-layer chromatography (TLC) with transparent crystal-like texture. Based on its infrared (IR) and
1
H nuclear magnetic resonance (NMR) spectra, the product was characterized as a tetrahydrofuran (THF)–acetate derivative (
2
). The highest conversion efficiencies of 57 and 60% were obtained when 8–9-day-old cell suspensions of
G. glabra
and
L. officinalis
were respectively fed with 4–7 mg of compound
1
in 40 ml of medium per culture and the cells were harvested after 2–5 days of incubation. The addition of compound
1
at the beginning of the culture cycle caused severe growth depression in a dose-dependent manner, resulting in poor bioconversion efficiency of ~25% at 2–5 mg/culture dose only.</description><identifier>ISSN: 1340-3443</identifier><identifier>EISSN: 1861-0293</identifier><identifier>DOI: 10.1007/s11418-011-0539-5</identifier><identifier>PMID: 21544685</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject>Artemisinins - chemistry ; Artemisinins - metabolism ; Artemisinins - pharmacology ; Biomedical and Life Sciences ; Biomedicine ; Cells, Cultured ; Chromatography, Thin Layer ; Complementary & Alternative Medicine ; Glycyrrhiza - cytology ; Glycyrrhiza - drug effects ; Glycyrrhiza - metabolism ; Lavandula - cytology ; Lavandula - drug effects ; Lavandula - metabolism ; Magnetic Resonance Spectroscopy ; Medicinal Chemistry ; Molecular Structure ; Pharmacology/Toxicology ; Pharmacy ; Plant Sciences</subject><ispartof>Journal of natural medicines, 2011-07, Vol.65 (3-4), p.646-650</ispartof><rights>The Japanese Society of Pharmacognosy and Springer 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-bfffe53c75899f5486f28bfd5f8a75a6a10ca965c15a5517fd76c33d0dc995d13</citedby><cites>FETCH-LOGICAL-c367t-bfffe53c75899f5486f28bfd5f8a75a6a10ca965c15a5517fd76c33d0dc995d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21544685$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patel, Suman</creatorcontrib><creatorcontrib>Gaur, Rashmi</creatorcontrib><creatorcontrib>Upadhyaya, Mohita</creatorcontrib><creatorcontrib>Mathur, Archana</creatorcontrib><creatorcontrib>Mathur, Ajay K.</creatorcontrib><creatorcontrib>Bhakuni, Rajendra S.</creatorcontrib><title>Glycyrrhiza glabra (Linn.) and Lavandula officinalis (L.) cell suspension cultures-based biotransformation of β-artemether</title><title>Journal of natural medicines</title><addtitle>J Nat Med</addtitle><addtitle>J Nat Med</addtitle><description>The biotransformation of β-artemether (
1
) by cell suspension cultures of
Glycyrrhiza glabra
and
Lavandula officinalis
is reported here for the first time. The major biotransformed product appeared as a grayish-blue color spot on thin-layer chromatography (TLC) with transparent crystal-like texture. Based on its infrared (IR) and
1
H nuclear magnetic resonance (NMR) spectra, the product was characterized as a tetrahydrofuran (THF)–acetate derivative (
2
). The highest conversion efficiencies of 57 and 60% were obtained when 8–9-day-old cell suspensions of
G. glabra
and
L. officinalis
were respectively fed with 4–7 mg of compound
1
in 40 ml of medium per culture and the cells were harvested after 2–5 days of incubation. The addition of compound
1
at the beginning of the culture cycle caused severe growth depression in a dose-dependent manner, resulting in poor bioconversion efficiency of ~25% at 2–5 mg/culture dose only.</description><subject>Artemisinins - chemistry</subject><subject>Artemisinins - metabolism</subject><subject>Artemisinins - pharmacology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cells, Cultured</subject><subject>Chromatography, Thin Layer</subject><subject>Complementary & Alternative Medicine</subject><subject>Glycyrrhiza - cytology</subject><subject>Glycyrrhiza - drug effects</subject><subject>Glycyrrhiza - metabolism</subject><subject>Lavandula - cytology</subject><subject>Lavandula - drug effects</subject><subject>Lavandula - metabolism</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medicinal Chemistry</subject><subject>Molecular Structure</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Plant Sciences</subject><issn>1340-3443</issn><issn>1861-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp9kM9u1DAQhy0EoqXwAFyQb8DBrR3_SXKsKihIK3GhZ2vi2K2rxN56kkrbvhUPwjPh1bYce5oZzTc_jT5CPgp-Kjhvz1AIJTrGhWBcy57pV-RYdKZOTS9f114qzqRS8oi8Q7zlXDVSirfkqBFaKdPpY_J4Oe3crpSb-AD0eoKhAP2yiSmdfqWQRrqB-1rWCWgOIbqYYIpYibp2fpoorrj1CWNO1K3TshaPbAD0Ix1iXgokDLnMsOyBHOjfPwzK4me_3PjynrwJMKH_8FRPyNX3b78vfrDNr8ufF-cb5qRpFzaEELyWrtVd3wetOhOabgijDh20GgwI7qA32gkNWos2jK1xUo58dH2vRyFPyOdD7rbku9XjYueI--8h-byi7dpGyd60ppLiQLqSEYsPdlviDGVnBbd75fag3Fbldq_c6nrz6Sl9HWY__r94dlyB5gBgXaVrX-xtXksViS-k_gNOvY6A</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>Patel, Suman</creator><creator>Gaur, Rashmi</creator><creator>Upadhyaya, Mohita</creator><creator>Mathur, Archana</creator><creator>Mathur, Ajay K.</creator><creator>Bhakuni, Rajendra S.</creator><general>Springer Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110701</creationdate><title>Glycyrrhiza glabra (Linn.) and Lavandula officinalis (L.) cell suspension cultures-based biotransformation of β-artemether</title><author>Patel, Suman ; Gaur, Rashmi ; Upadhyaya, Mohita ; Mathur, Archana ; Mathur, Ajay K. ; Bhakuni, Rajendra S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-bfffe53c75899f5486f28bfd5f8a75a6a10ca965c15a5517fd76c33d0dc995d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Artemisinins - chemistry</topic><topic>Artemisinins - metabolism</topic><topic>Artemisinins - pharmacology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cells, Cultured</topic><topic>Chromatography, Thin Layer</topic><topic>Complementary & Alternative Medicine</topic><topic>Glycyrrhiza - cytology</topic><topic>Glycyrrhiza - drug effects</topic><topic>Glycyrrhiza - metabolism</topic><topic>Lavandula - cytology</topic><topic>Lavandula - drug effects</topic><topic>Lavandula - metabolism</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medicinal Chemistry</topic><topic>Molecular Structure</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Plant Sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patel, Suman</creatorcontrib><creatorcontrib>Gaur, Rashmi</creatorcontrib><creatorcontrib>Upadhyaya, Mohita</creatorcontrib><creatorcontrib>Mathur, Archana</creatorcontrib><creatorcontrib>Mathur, Ajay K.</creatorcontrib><creatorcontrib>Bhakuni, Rajendra S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patel, Suman</au><au>Gaur, Rashmi</au><au>Upadhyaya, Mohita</au><au>Mathur, Archana</au><au>Mathur, Ajay K.</au><au>Bhakuni, Rajendra S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glycyrrhiza glabra (Linn.) and Lavandula officinalis (L.) cell suspension cultures-based biotransformation of β-artemether</atitle><jtitle>Journal of natural medicines</jtitle><stitle>J Nat Med</stitle><addtitle>J Nat Med</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>65</volume><issue>3-4</issue><spage>646</spage><epage>650</epage><pages>646-650</pages><issn>1340-3443</issn><eissn>1861-0293</eissn><abstract>The biotransformation of β-artemether (
1
) by cell suspension cultures of
Glycyrrhiza glabra
and
Lavandula officinalis
is reported here for the first time. The major biotransformed product appeared as a grayish-blue color spot on thin-layer chromatography (TLC) with transparent crystal-like texture. Based on its infrared (IR) and
1
H nuclear magnetic resonance (NMR) spectra, the product was characterized as a tetrahydrofuran (THF)–acetate derivative (
2
). The highest conversion efficiencies of 57 and 60% were obtained when 8–9-day-old cell suspensions of
G. glabra
and
L. officinalis
were respectively fed with 4–7 mg of compound
1
in 40 ml of medium per culture and the cells were harvested after 2–5 days of incubation. The addition of compound
1
at the beginning of the culture cycle caused severe growth depression in a dose-dependent manner, resulting in poor bioconversion efficiency of ~25% at 2–5 mg/culture dose only.</abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>21544685</pmid><doi>10.1007/s11418-011-0539-5</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1340-3443 |
| ispartof | Journal of natural medicines, 2011-07, Vol.65 (3-4), p.646-650 |
| issn | 1340-3443 1861-0293 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_872439676 |
| source | Springer Nature |
| subjects | Artemisinins - chemistry Artemisinins - metabolism Artemisinins - pharmacology Biomedical and Life Sciences Biomedicine Cells, Cultured Chromatography, Thin Layer Complementary & Alternative Medicine Glycyrrhiza - cytology Glycyrrhiza - drug effects Glycyrrhiza - metabolism Lavandula - cytology Lavandula - drug effects Lavandula - metabolism Magnetic Resonance Spectroscopy Medicinal Chemistry Molecular Structure Pharmacology/Toxicology Pharmacy Plant Sciences |
| title | Glycyrrhiza glabra (Linn.) and Lavandula officinalis (L.) cell suspension cultures-based biotransformation of β-artemether |
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