Near-infrared spectroscopy of orbitofrontal cortex during odorant stimulation

For olfaction, several studies have reported near-infrared spectroscopy (NIRS) signal changes in the orbitofrontal cortex (OFC) during odor stimulation. However, the roles of human OFC in olfactory cognition are less well understood. This study was designed to better understand the roles of OFC for...

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Published in:American journal of rhinology & allergy 2011-05, Vol.25 (3), p.163-165
Main Authors: Kokan, Norio, Sakai, Nobuyuki, Doi, Kiyoshi, Fujio, Hisami, Hasegawa, Shingo, Tanimoto, Hitoshi, Nibu, Ken-Ichi
Format: Article
Language:English
Subjects:
Adolescent
Cerebral Cortex
Ethanol - analysis
Female
Frontal Lobe - metabolism
Frontal Lobe - radiation effects
Hemoglobins - metabolism
Humans
Infrared Rays - adverse effects
Monoterpenes - analysis
Neuroanatomy - methods
Neuroanatomy - trends
Odorants - analysis
Smell - physiology
Spectroscopy, Near-Infrared
Surveys and Questionnaires
Young Adult
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Summary:For olfaction, several studies have reported near-infrared spectroscopy (NIRS) signal changes in the orbitofrontal cortex (OFC) during odor stimulation. However, the roles of human OFC in olfactory cognition are less well understood. This study was designed to better understand the roles of OFC for olfaction. Hemodynamic responses for phenyl ethyl alcohol or citral in the OFCs were measured with NIRS. After the experiment, participants were asked to describe the characteristics of the odor and to rate odor intensity and hedonic valence. Statistical analysis of all participants' data showed significant changes in the concentration of total hemoglobin in the left OFC during the trial (p = 0.04). The total hemoglobin signal increased significantly in the right OFC (p = 0.0008) of the participants who successfully identified the odorant stimulus. Our findings showed that NIRS combined with a questionnaire is a useful method for studying the functional neuroanatomy of OFC in terms of olfaction.
ISSN:1945-8924
1945-8932
DOI:10.2500/ajra.2011.25.3634