Proteins mediating collagen biosynthesis and accumulation in arterial repair: novel targets for anti-restenosis therapy

Events contributing to restenosis after coronary interventions include platelet aggregation, inflammatory cell infiltration, growth factor release, and accumulation of smooth muscle cells (SMCs) and extracellular matrix (ECM). The ECM is composed of various collagen subtypes and proteoglycans and ov...

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Bibliographic Details
Published in:Cardiovascular research 2011-07, Vol.91 (1), p.16-26
Main Authors: Osherov, Azriel B., Gotha, Lara, Cheema, Asim N., Qiang, Beiping, Strauss, Bradley H.
Format: Article
Language:English
Subjects:
Angioplasty, Balloon, Coronary - adverse effects
Angioplasty, Balloon, Coronary - instrumentation
Animals
Biological and medical sciences
Cardiology. Vascular system
Cardiovascular Agents - pharmacology
Collagen - biosynthesis
Collagen - metabolism
Collagenases - metabolism
Coronary Restenosis - etiology
Coronary Restenosis - metabolism
Coronary Restenosis - prevention & control
Coronary Stenosis - therapy
Cytokines - antagonists & inhibitors
Cytokines - metabolism
Diseases of the cardiovascular system
Enzyme Inhibitors - pharmacology
Humans
Integrins - antagonists & inhibitors
Integrins - metabolism
Intercellular Signaling Peptides and Proteins - metabolism
Matrix Metalloproteinase Inhibitors
Medical sciences
Protein-Lysine 6-Oxidase - antagonists & inhibitors
Protein-Lysine 6-Oxidase - metabolism
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Signal Transduction - drug effects
Stents
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Description
Summary:Events contributing to restenosis after coronary interventions include platelet aggregation, inflammatory cell infiltration, growth factor release, and accumulation of smooth muscle cells (SMCs) and extracellular matrix (ECM). The ECM is composed of various collagen subtypes and proteoglycans and over time constitutes the major component of the mature restenotic plaque. The pathophysiology of collagen accumulation in the ECM during arterial restenosis is reviewed. Factors regulating collagen synthesis and degradation, including various cytokines and growth factors involved in the process, may be targets for therapies aimed at prevention of in-stent restenosis.
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/cvr012