Transcriptional mechanisms regulating Ca(2+) homeostasis

Ca(2+) is a dynamic cellular secondary messenger which mediates a vast array of cellular responses. Control over these processes is achieved via an extensive combination of pumps and channels which regulate the concentration of Ca(2+) within not only the cytosol but also all intracellular compartmen...

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Bibliographic Details
Published in:Cell calcium (Edinburgh) 2011-05, Vol.49 (5), p.314-321
Main Authors: Ritchie, Michael F, Zhou, Yandong, Soboloff, Jonathan
Format: Article
Language:English
Subjects:
Animals
Calcium - metabolism
Calcium Channels
Calcium Signaling
Early Growth Response Protein 1 - metabolism
Homeostasis
Membrane Glycoproteins - genetics
Membrane Glycoproteins - metabolism
Mice
Plasma Membrane Calcium-Transporting ATPases - genetics
Plasma Membrane Calcium-Transporting ATPases - metabolism
Sarcoplasmic Reticulum Calcium-Transporting ATPases - genetics
Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism
Stromal Interaction Molecule 1
Transcription, Genetic
WT1 Proteins - metabolism
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Summary:Ca(2+) is a dynamic cellular secondary messenger which mediates a vast array of cellular responses. Control over these processes is achieved via an extensive combination of pumps and channels which regulate the concentration of Ca(2+) within not only the cytosol but also all intracellular compartments. Precisely how these pumps and channels are regulated is only partially understood, however, recent investigations have identified members of the Early Growth Response (EGR) family of zinc finger transcription factors as critical players in this process. The roles of several other transcription factors in control of Ca(2+) homeostasis have also been demonstrated, including Wilms Tumor Suppressor 1 (WT1), Nuclear Factor of Activated T cells (NFAT) and c-myc. In this review, we will discuss not only how these transcription factors regulate the expression of the major proteins involved in control of Ca(2+) homeostasis, but also how this transcriptional remodeling of Ca(2+) homeostasis affects Ca(2+) dynamics and cellular responses.
ISSN:1532-1991
DOI:10.1016/j.ceca.2010.10.001