Solid phase combinatorial synthesis of a xanthone library using click chemistry and its application to an embryonic stem cell probe

We report the first solid phase synthesis of a xanthone library CX and its application to embryonic stem cell probe development. The CX library was further derivatised with an activated ester resin to provide an acetylated CX (CXAC) library. Screening of these libraries led to the discovery of a nov...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2011-07, Vol.47 (26), p.7488-7490
Main Authors: Ghosh, Krishna Kanta, Ha, Hyung-Ho, Kang, Nam-Young, Chandran, Yogeswari, Chang, Young-Tae
Format: Article
Language:English
Subjects:
Animals
Click Chemistry
Combinatorial Chemistry Techniques - methods
Embryonic Stem Cells - metabolism
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Fluorescent Dyes - metabolism
Mice
Small Molecule Libraries - chemical synthesis
Small Molecule Libraries - chemistry
Small Molecule Libraries - metabolism
Xanthones - chemical synthesis
Xanthones - chemistry
Xanthones - metabolism
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Summary:We report the first solid phase synthesis of a xanthone library CX and its application to embryonic stem cell probe development. The CX library was further derivatised with an activated ester resin to provide an acetylated CX (CXAC) library. Screening of these libraries led to the discovery of a novel fluorescent mESC probe, CDb8.
ISSN:1359-7345
1364-548X
DOI:10.1039/c1cc11962a