Self-Assembly of a Bifunctional DNA Carrier for Drug Delivery

Speedy delivery: A self‐assembled bifunctional unit incorporates a DNA aptamer for target recognition (see picture, green helix) and a G‐quadruplex for drug loading. The modified DNA selectively delivered a photosensitizer (red bars) to cancer cells; irradiation with visible light generated high tox...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2011-06, Vol.50 (27), p.6098-6101
Main Authors: Wang, Kelong, You, Mingxu, Chen, Yan, Han, Da, Zhu, Zhi, Huang, Jin, Williams, Kathryn, Yang, Chaoyong James, Tan, Weihong
Format: Article
Language:English
Subjects:
aptamers
Aptamers, Nucleotide - chemistry
Aptamers, Nucleotide - pharmacology
Base Sequence
Burkitt Lymphoma - therapy
Cell Line, Tumor
Cell Survival
DNA
DNA - pharmacology
drug delivery
Drug Delivery Systems - methods
Flow Cytometry
G-Quadruplexes
Humans
Phototherapy - methods
Porphyrins
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - therapy
self-assembly
Spectrum Analysis
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Summary:Speedy delivery: A self‐assembled bifunctional unit incorporates a DNA aptamer for target recognition (see picture, green helix) and a G‐quadruplex for drug loading. The modified DNA selectively delivered a photosensitizer (red bars) to cancer cells; irradiation with visible light generated high toxicity.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201008053