Association of the Metabolic Syndrome and Long-Term Renal Function in Kidney Donors

Abstract Background Metabolic syndrome (MetS) may represent risk factor for long-term renal function of kidneys from living donors. The aim of this study was to evaluate the impact of MetS on renal function in donors. Methods Data regarding the presence or absence of MetS and renal function, as asse...

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Bibliographic Details
Published in:Transplantation proceedings 2011-06, Vol.43 (5), p.1601-1606
Main Authors: Cuevas-Ramos, D, Almeda-Valdés, P, Arvizu, M, Mata, J, Morales-Buenrostro, L.E, Gabilondo, B, Vilatobá, M, Correa-Rotter, R, Gabilondo-Navarro, F, Mehta, R, Aguilar-Salinas, C.A, Alberú, J, Gómez-Pérez, F.J
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Glomerular Filtration Rate
Humans
Kidney - physiopathology
Male
Medical sciences
Metabolic diseases
Metabolic Syndrome - physiopathology
Middle Aged
Miscellaneous
Other metabolic disorders
Proportional Hazards Models
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Tissue Donors
Tissue, organ and graft immunology
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Summary:Abstract Background Metabolic syndrome (MetS) may represent risk factor for long-term renal function of kidneys from living donors. The aim of this study was to evaluate the impact of MetS on renal function in donors. Methods Data regarding the presence or absence of MetS and renal function, as assessed by estimated glomerular filtration rate (eGFR) were obtained from 140 kidney donors before nephrectomy (BN) and at follow-up (AF). Donors were divided into those with (group 1; n =28) versus without MetS (group 2; n = 112). Results Comparing the groups, we observed a significantly greater reduction in eGFR among the group with MetS BN versus AF 27.5% (19.3–33.0) versus 21.4% (9.6–34.1 P = .02) respectively using a Cox regression model, including age, gender, serum uric acid, body mass index (BMI), and basal eGFR, MetS BN (hazard ratio = 2.2; 95% confidence interval [CI], 1.21–4.01; p = .01) was an independent factor associated with a greater risk of a-eGFR
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2011.02.058