Carbohydrate Does Not Augment Exercise-Induced Protein Accretion versus Protein Alone

• Published in: Medicine and science in sports and exercise 2011-07, Vol.43 (7), p.1154-1161
• Main Authors: STAPLES, Aaron W, BURD, Nicholas A, WEST, Daniel W. D, CURRIE, Katharine D, ATHERTON, Philip J, MOORE, Daniel R, RENNIE, Michael J, MACDONALD, Maureen J, BAKER, Steven K, PHILLIPS, Stuart M
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Dietary Carbohydrates - administration & dosage; Dietary Carbohydrates - metabolism; Dietary Proteins - administration & dosage; Dietary Proteins - metabolism; Eating; Exercise; Fundamental and applied biological sciences. Psychology; Humans; Insulin - blood; Knee - physiology; Male; Milk Proteins - administration & dosage; Milk Proteins - metabolism; Muscle Proteins - biosynthesis; Muscle Proteins - metabolism; Muscle, Skeletal - metabolism; Polysaccharides - administration & dosage; Polysaccharides - metabolism; Protein Kinases - metabolism; Proto-Oncogene Proteins c-akt - metabolism; Space life sciences; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports; Whey Proteins; Young Adult
• ISSN: 0195-9131; 1530-0315
• DOI: 10.1249/MSS.0b013e31820751cb

We tested the thesis that CHO and protein coingestion would augment muscle protein synthesis (MPS) and inhibit muscle protein breakdown (MPB) at rest and after resistance exercise. Nine men (age=23.0±1.9 yr, body mass index=24.2±2.1 kg·m) performed two unilateral knee extension trials (four sets×8-12 repetitions to failure) followed by consumption of 25 g of whey protein (PRO) or 25 g of whey protein plus 50 g of maltodextrin (PRO+CARB). Muscle biopsies and stable isotope methodology were used to measure MPS and MPB. The areas under the glucose and insulin curves were 17.5-fold (P