Particulate vaccines: on the quest for optimal delivery and immune response

Subunit vaccines offer a safer alternative to traditional organism-based vaccines, but their immunogenicity is impaired. This hurdle might be overcome by the use of micro- and nanodelivery systems carrying the antigen(s). This review discusses the rationale for the use of particulate vaccines and pr...

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Bibliographic Details
Published in:Drug discovery today 2011-07, Vol.16 (13), p.569-582
Main Authors: De Temmerman, Marie-Luce, Rejman, Joanna, Demeester, Jo, Irvine, Darrell J., Gander, Bruno, De Smedt, Stefaan C.
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - administration & dosage
Animals
Antigen presentation
Antigen-Presenting Cells - immunology
Antigens - administration & dosage
Antigens - immunology
Biological and medical sciences
Drug Delivery Systems
General pharmacology
Humans
Medical sciences
Microspheres
Nanoparticles
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Vaccines - administration & dosage
Vaccines - adverse effects
Vaccines - immunology
Vaccines, Subunit - administration & dosage
Vaccines, Subunit - adverse effects
Vaccines, Subunit - immunology
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Summary:Subunit vaccines offer a safer alternative to traditional organism-based vaccines, but their immunogenicity is impaired. This hurdle might be overcome by the use of micro- and nanodelivery systems carrying the antigen(s). This review discusses the rationale for the use of particulate vaccines and provides an overview of antigen-delivery vehicles currently under investigation. It further highlights the cellular uptake, antigen processing and the presentation by antigen-presenting cells because these processes are partially governed by particle characteristics and eventually determine the immunological outcome. Finally, we address the attractive concept of concomitant delivery of antigens and immunopotentiators. The condensed knowledge could be an asset for rationally designing antigen-delivery vehicles to obtain safe and efficacious vaccines. Reviewing the rationale for the design of particulate vaccines and how particle characteristics influence internalization, processing and antigen presentation by APCs.
ISSN:1359-6446
1878-5832
DOI:10.1016/j.drudis.2011.04.006