Oxidative DNA damage in patients with cataract

Acta Ophthalmol. 2010: 88: 891–895 . Purpose:  This study examines the levels of oxidative damage in patients with cataract. Methods:  Blood samples were collected from 60 patients with cataract and 60 age‐ and gender‐matched healthy individuals to measure 8‐hydroxy 2‐deoxyguanosine (8‐OHdG) and mal...

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Published in:Acta ophthalmologica (Oxford, England) England), 2010-12, Vol.88 (8), p.891-895
Main Authors: Ates, Orhan, Alp, Hakan Hamit, Kocer, Ibrahim, Baykal, Orhan, Salman, İlknur A.
Format: Article
Language:English
Subjects:
Aged
Aging - physiology
cataract
Cataract - blood
Cataract - genetics
Cataracts
Chromatography, High Pressure Liquid
Deoxyguanosine - analogs & derivatives
Deoxyguanosine - blood
DNA Damage
Female
Humans
Leukocytes
Leukocytes - metabolism
Lipid Peroxidation
Male
Malondialdehyde
Malondialdehyde - blood
Middle Aged
oxidative DNA damage
Oxidative Stress
Reactive Oxygen Species - metabolism
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Summary:Acta Ophthalmol. 2010: 88: 891–895 . Purpose:  This study examines the levels of oxidative damage in patients with cataract. Methods:  Blood samples were collected from 60 patients with cataract and 60 age‐ and gender‐matched healthy individuals to measure 8‐hydroxy 2‐deoxyguanosine (8‐OHdG) and malondialdehyde (MDA) levels. Results:  A significant difference was observed in leukocyte 8‐OHdG levels in patients with cataract in comparison with healthy persons (p 
ISSN:1755-375X
1755-3768
DOI:10.1111/j.1755-3768.2009.01583.x