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Oxidative DNA damage in patients with cataract
Acta Ophthalmol. 2010: 88: 891–895 . Purpose: This study examines the levels of oxidative damage in patients with cataract. Methods: Blood samples were collected from 60 patients with cataract and 60 age‐ and gender‐matched healthy individuals to measure 8‐hydroxy 2‐deoxyguanosine (8‐OHdG) and mal...
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| Published in: | Acta ophthalmologica (Oxford, England) England), 2010-12, Vol.88 (8), p.891-895 |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c4003-df42000b75887bba22bf552b5845af9209de8dd19faef9706eb23cc2ae2e26923 |
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| cites | cdi_FETCH-LOGICAL-c4003-df42000b75887bba22bf552b5845af9209de8dd19faef9706eb23cc2ae2e26923 |
| container_end_page | 895 |
| container_issue | 8 |
| container_start_page | 891 |
| container_title | Acta ophthalmologica (Oxford, England) |
| container_volume | 88 |
| creator | Ates, Orhan Alp, Hakan Hamit Kocer, Ibrahim Baykal, Orhan Salman, İlknur A. |
| description | Acta Ophthalmol. 2010: 88: 891–895
.
Purpose: This study examines the levels of oxidative damage in patients with cataract.
Methods: Blood samples were collected from 60 patients with cataract and 60 age‐ and gender‐matched healthy individuals to measure 8‐hydroxy 2‐deoxyguanosine (8‐OHdG) and malondialdehyde (MDA) levels.
Results: A significant difference was observed in leukocyte 8‐OHdG levels in patients with cataract in comparison with healthy persons (p |
| doi_str_mv | 10.1111/j.1755-3768.2009.01583.x |
| format | article |
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.
Purpose: This study examines the levels of oxidative damage in patients with cataract.
Methods: Blood samples were collected from 60 patients with cataract and 60 age‐ and gender‐matched healthy individuals to measure 8‐hydroxy 2‐deoxyguanosine (8‐OHdG) and malondialdehyde (MDA) levels.
Results: A significant difference was observed in leukocyte 8‐OHdG levels in patients with cataract in comparison with healthy persons (p < 0.001). Similarly, a significant difference was observed in plasma MDA levels in patients with cataract in comparison with healthy persons (p < 0.001). In addition, a significant correlation was found between levels of 8‐OHdG in leukocyte DNA and plasma MDA (r = 0.859, p < 0.001).
Conclusion: This study measured the oxidative DNA damage by measuring the 8‐OHdG in the leukocyte DNA in patients with cataract. In addition, the level of MDA – a marker for lipid peroxidation – was measured to determine lipid peroxidation.</description><identifier>ISSN: 1755-375X</identifier><identifier>EISSN: 1755-3768</identifier><identifier>DOI: 10.1111/j.1755-3768.2009.01583.x</identifier><identifier>PMID: 19706013</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Aged ; Aging - physiology ; cataract ; Cataract - blood ; Cataract - genetics ; Cataracts ; Chromatography, High Pressure Liquid ; Deoxyguanosine - analogs & derivatives ; Deoxyguanosine - blood ; DNA Damage ; Female ; Humans ; Leukocytes ; Leukocytes - metabolism ; Lipid Peroxidation ; Male ; Malondialdehyde ; Malondialdehyde - blood ; Middle Aged ; oxidative DNA damage ; Oxidative Stress ; Reactive Oxygen Species - metabolism</subject><ispartof>Acta ophthalmologica (Oxford, England), 2010-12, Vol.88 (8), p.891-895</ispartof><rights>2009 The Authors. Journal compilation © 2009 Acta Ophthalmol</rights><rights>2009 The Authors. Journal compilation © 2009 Acta Ophthalmol.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4003-df42000b75887bba22bf552b5845af9209de8dd19faef9706eb23cc2ae2e26923</citedby><cites>FETCH-LOGICAL-c4003-df42000b75887bba22bf552b5845af9209de8dd19faef9706eb23cc2ae2e26923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19706013$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ates, Orhan</creatorcontrib><creatorcontrib>Alp, Hakan Hamit</creatorcontrib><creatorcontrib>Kocer, Ibrahim</creatorcontrib><creatorcontrib>Baykal, Orhan</creatorcontrib><creatorcontrib>Salman, İlknur A.</creatorcontrib><title>Oxidative DNA damage in patients with cataract</title><title>Acta ophthalmologica (Oxford, England)</title><addtitle>Acta Ophthalmol</addtitle><description>Acta Ophthalmol. 2010: 88: 891–895
.
Purpose: This study examines the levels of oxidative damage in patients with cataract.
Methods: Blood samples were collected from 60 patients with cataract and 60 age‐ and gender‐matched healthy individuals to measure 8‐hydroxy 2‐deoxyguanosine (8‐OHdG) and malondialdehyde (MDA) levels.
Results: A significant difference was observed in leukocyte 8‐OHdG levels in patients with cataract in comparison with healthy persons (p < 0.001). Similarly, a significant difference was observed in plasma MDA levels in patients with cataract in comparison with healthy persons (p < 0.001). In addition, a significant correlation was found between levels of 8‐OHdG in leukocyte DNA and plasma MDA (r = 0.859, p < 0.001).
Conclusion: This study measured the oxidative DNA damage by measuring the 8‐OHdG in the leukocyte DNA in patients with cataract. In addition, the level of MDA – a marker for lipid peroxidation – was measured to determine lipid peroxidation.</description><subject>Aged</subject><subject>Aging - physiology</subject><subject>cataract</subject><subject>Cataract - blood</subject><subject>Cataract - genetics</subject><subject>Cataracts</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Deoxyguanosine - analogs & derivatives</subject><subject>Deoxyguanosine - blood</subject><subject>DNA Damage</subject><subject>Female</subject><subject>Humans</subject><subject>Leukocytes</subject><subject>Leukocytes - metabolism</subject><subject>Lipid Peroxidation</subject><subject>Male</subject><subject>Malondialdehyde</subject><subject>Malondialdehyde - blood</subject><subject>Middle Aged</subject><subject>oxidative DNA damage</subject><subject>Oxidative Stress</subject><subject>Reactive Oxygen Species - metabolism</subject><issn>1755-375X</issn><issn>1755-3768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqNkDtPwzAQgC0EoqXwF1A2poSzHSf2wFCVp1TRAZDYLNu5QKqkLXH6-vcktCojePHp7ruHPkICChFt3_U0oqkQIU8TGTEAFQEVkkebI9I_FI4PsXjvkTPvpwAJTZL4lPSoSiEByvskmmyKzDTFCoPb52GQmcp8YFDMgkWbxFnjg3XRfAbONKY2rjknJ7kpPV7s_wF5u797HT2G48nD02g4Dl0MwMMsj9uzwKZCytRaw5jNhWBWyFiYXDFQGcosoyo3mHe3oGXcOWaQIUsU4wNytZu7qOdfS_SNrgrvsCzNDOdLr2Ua01QJJf8mqRACOPCWlDvS1XPva8z1oi4qU281Bd1p1VPdGdOdPd1p1T9a9aZtvdwvWdoKs9_GvccWuNkB66LE7b8H6-HkpYv4Nx0zhGw</recordid><startdate>201012</startdate><enddate>201012</enddate><creator>Ates, Orhan</creator><creator>Alp, Hakan Hamit</creator><creator>Kocer, Ibrahim</creator><creator>Baykal, Orhan</creator><creator>Salman, İlknur A.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TM</scope></search><sort><creationdate>201012</creationdate><title>Oxidative DNA damage in patients with cataract</title><author>Ates, Orhan ; Alp, Hakan Hamit ; Kocer, Ibrahim ; Baykal, Orhan ; Salman, İlknur A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4003-df42000b75887bba22bf552b5845af9209de8dd19faef9706eb23cc2ae2e26923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Aging - physiology</topic><topic>cataract</topic><topic>Cataract - blood</topic><topic>Cataract - genetics</topic><topic>Cataracts</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Deoxyguanosine - analogs & derivatives</topic><topic>Deoxyguanosine - blood</topic><topic>DNA Damage</topic><topic>Female</topic><topic>Humans</topic><topic>Leukocytes</topic><topic>Leukocytes - metabolism</topic><topic>Lipid Peroxidation</topic><topic>Male</topic><topic>Malondialdehyde</topic><topic>Malondialdehyde - blood</topic><topic>Middle Aged</topic><topic>oxidative DNA damage</topic><topic>Oxidative Stress</topic><topic>Reactive Oxygen Species - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ates, Orhan</creatorcontrib><creatorcontrib>Alp, Hakan Hamit</creatorcontrib><creatorcontrib>Kocer, Ibrahim</creatorcontrib><creatorcontrib>Baykal, Orhan</creatorcontrib><creatorcontrib>Salman, İlknur A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Nucleic Acids Abstracts</collection><jtitle>Acta ophthalmologica (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ates, Orhan</au><au>Alp, Hakan Hamit</au><au>Kocer, Ibrahim</au><au>Baykal, Orhan</au><au>Salman, İlknur A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxidative DNA damage in patients with cataract</atitle><jtitle>Acta ophthalmologica (Oxford, England)</jtitle><addtitle>Acta Ophthalmol</addtitle><date>2010-12</date><risdate>2010</risdate><volume>88</volume><issue>8</issue><spage>891</spage><epage>895</epage><pages>891-895</pages><issn>1755-375X</issn><eissn>1755-3768</eissn><abstract>Acta Ophthalmol. 2010: 88: 891–895
.
Purpose: This study examines the levels of oxidative damage in patients with cataract.
Methods: Blood samples were collected from 60 patients with cataract and 60 age‐ and gender‐matched healthy individuals to measure 8‐hydroxy 2‐deoxyguanosine (8‐OHdG) and malondialdehyde (MDA) levels.
Results: A significant difference was observed in leukocyte 8‐OHdG levels in patients with cataract in comparison with healthy persons (p < 0.001). Similarly, a significant difference was observed in plasma MDA levels in patients with cataract in comparison with healthy persons (p < 0.001). In addition, a significant correlation was found between levels of 8‐OHdG in leukocyte DNA and plasma MDA (r = 0.859, p < 0.001).
Conclusion: This study measured the oxidative DNA damage by measuring the 8‐OHdG in the leukocyte DNA in patients with cataract. In addition, the level of MDA – a marker for lipid peroxidation – was measured to determine lipid peroxidation.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19706013</pmid><doi>10.1111/j.1755-3768.2009.01583.x</doi><tpages>5</tpages></addata></record> |
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| ispartof | Acta ophthalmologica (Oxford, England), 2010-12, Vol.88 (8), p.891-895 |
| issn | 1755-375X 1755-3768 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Aged Aging - physiology cataract Cataract - blood Cataract - genetics Cataracts Chromatography, High Pressure Liquid Deoxyguanosine - analogs & derivatives Deoxyguanosine - blood DNA Damage Female Humans Leukocytes Leukocytes - metabolism Lipid Peroxidation Male Malondialdehyde Malondialdehyde - blood Middle Aged oxidative DNA damage Oxidative Stress Reactive Oxygen Species - metabolism |
| title | Oxidative DNA damage in patients with cataract |
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