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Increased HDAC1 deposition at hematopoietic promoters in AML and its association with patient survival

Abstract Epigenetic changes play a crucial role in leukemogenesis. HDACs are frequently recruited to target gene promoters by balanced translocation derived oncogenic fusion proteins. As important epigenetic effector mechanisms, histone deacetylases (HDAC) have emerged as potential therapeutic targe...

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Published in:Leukemia research 2011-05, Vol.35 (5), p.620-625
Main Authors: Tickenbrock, Lara, Klein, Hans-Ulrich, Trento, Cristina, Hascher, Antje, Göllner, Stefanie, Bäumer, Nicole, Kuss, Robert, Agrawal, Shuchi, Bug, Gesine, Serve, Hubert, Thiede, Christian, Ehninger, Gerhard, Stadt, Udo zur, McClelland, Michael, Wang, Yipeng, Becker, Anke, Koschmieder, Steffen, Berdel, Wolfgang E, Dugas, Martin, Müller-Tidow, Carsten
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cited_by cdi_FETCH-LOGICAL-c451t-e75f121cc907f4227b6635f0aba140ac361bf5c1832c374a6e2782b5fdedf0473
cites cdi_FETCH-LOGICAL-c451t-e75f121cc907f4227b6635f0aba140ac361bf5c1832c374a6e2782b5fdedf0473
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container_title Leukemia research
container_volume 35
creator Tickenbrock, Lara
Klein, Hans-Ulrich
Trento, Cristina
Hascher, Antje
Göllner, Stefanie
Bäumer, Nicole
Kuss, Robert
Agrawal, Shuchi
Bug, Gesine
Serve, Hubert
Thiede, Christian
Ehninger, Gerhard
Stadt, Udo zur
McClelland, Michael
Wang, Yipeng
Becker, Anke
Koschmieder, Steffen
Berdel, Wolfgang E
Dugas, Martin
Müller-Tidow, Carsten
description Abstract Epigenetic changes play a crucial role in leukemogenesis. HDACs are frequently recruited to target gene promoters by balanced translocation derived oncogenic fusion proteins. As important epigenetic effector mechanisms, histone deacetylases (HDAC) have emerged as potential therapeutic targets. However, the patterns of HDAC1 localization and the role of HDACs in leukemia pathogenesis remain to be elucidated. Using ChIP-Chip analyses we analyzed HDAC1 deposition patterns at more than 10,000 gene promoters in a large cohort of leukemia patients and CD34+ controls. HDAC1 binding was significantly increased in AML blasts compared to CD34+ progenitor cells at 130 gene promoters whereas decreased binding was observed at 66 gene promoters. Distinct HDAC1 binding patterns occurred in AML subtypes with balanced translocations t (15;17), t (8;21) and inv(16). In addition, a more generalized signature was established, that revealed an AML specific pattern of HDAC1 distribution. Many of the HDAC1-binding altered promoters regulate genes involved in hematopoiesis, transcriptional regulation and signal transduction. HDAC1 binding patterns were associated with patients’ event free survival. This is the first study to determine HDAC1 modification patterns in a large number of AML and ALL specimens. Our findings suggest that dyslocalization of HDAC1 is a common feature in AML. Importantly, HDAC1 modifications possess prognostic power for patient survival. Our findings suggest that altered HDAC1 localization is an explanation for the observed benefit of HDAC inhibitors in AML therapy.
doi_str_mv 10.1016/j.leukres.2010.11.006
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HDACs are frequently recruited to target gene promoters by balanced translocation derived oncogenic fusion proteins. As important epigenetic effector mechanisms, histone deacetylases (HDAC) have emerged as potential therapeutic targets. However, the patterns of HDAC1 localization and the role of HDACs in leukemia pathogenesis remain to be elucidated. Using ChIP-Chip analyses we analyzed HDAC1 deposition patterns at more than 10,000 gene promoters in a large cohort of leukemia patients and CD34+ controls. HDAC1 binding was significantly increased in AML blasts compared to CD34+ progenitor cells at 130 gene promoters whereas decreased binding was observed at 66 gene promoters. Distinct HDAC1 binding patterns occurred in AML subtypes with balanced translocations t (15;17), t (8;21) and inv(16). In addition, a more generalized signature was established, that revealed an AML specific pattern of HDAC1 distribution. Many of the HDAC1-binding altered promoters regulate genes involved in hematopoiesis, transcriptional regulation and signal transduction. HDAC1 binding patterns were associated with patients’ event free survival. This is the first study to determine HDAC1 modification patterns in a large number of AML and ALL specimens. Our findings suggest that dyslocalization of HDAC1 is a common feature in AML. Importantly, HDAC1 modifications possess prognostic power for patient survival. 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subjects Adolescent
Adult
Aged
AML
Biomarkers, Tumor - metabolism
Child
Child, Preschool
ChIP
Chromatin - metabolism
Female
HDAC
Hematology, Oncology and Palliative Medicine
Hematopoiesis - genetics
Histone Deacetylase 1 - metabolism
Humans
Infant
Leukemia, Myeloid, Acute - diagnosis
Leukemia, Myeloid, Acute - genetics
Leukemia, Myeloid, Acute - metabolism
Leukemia, Myeloid, Acute - mortality
Male
Middle Aged
Prognosis
Promoter Regions, Genetic - physiology
Protein Binding - physiology
Survival Analysis
Young Adult
title Increased HDAC1 deposition at hematopoietic promoters in AML and its association with patient survival
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