Embryology of the hindgut

Normal and abnormal development of the hindgut is still in debate. Normal development of the hindgut critically depends on the cloacal membrane. In this study, scanning electron microscopy of staged rat embryos between the gestational days 10-15 was performed to show the normal development of the hi...

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Bibliographic Details
Published in:Seminars in pediatric surgery 2011-08, Vol.20 (3), p.152-160
Main Authors: Kluth, Dietrich, MD, PhD, Fiegel, Henning C., MD, PhD, Metzger, Roman, MD, PhD
Format: Article
Language:English
Subjects:
Anal Canal - abnormalities
Anal Canal - embryology
Animals
Anorectal malformation (ARM)
Anorectal Malformations
Anus, Imperforate - embryology
Cloaca - abnormalities
Cloaca - embryology
Colon - abnormalities
Colon - embryology
Embryology
Female
Hindgut
Mice
Microscopy, Electron, Scanning
Pediatrics
Rats
Rectum - abnormalities
Rectum - embryology
Scanning electron microscopy (SEM)
Surgery
Urogenital System - embryology
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Summary:Normal and abnormal development of the hindgut is still in debate. Normal development of the hindgut critically depends on the cloacal membrane. In this study, scanning electron microscopy of staged rat embryos between the gestational days 10-15 was performed to show the normal development of the hindgut and the abnormal development in Danforth's short tail (SD) mice. Our studies in normal and abnormal development indicate that the embryonic cloaca never passes through a stage that is similar to any form of anorectal malformation in neonates, including the so-called “cloacas” in females. To explain the abnormal development in anorectal malformations, further studies are mandatory.
ISSN:1055-8586
1532-9453
DOI:10.1053/j.sempedsurg.2011.03.002