Synthesis and antibacterial activity of alaremycin derivatives for the porphobilinogen synthase

The preparation and the antibacterial activity of alaremycin derivatives such as their CF 3-derivatives and ( R)- and ( S)-4-oxo-5-acetylaminohexanoic acid for the porphobilinogen synthase (PBGS), were described. The IC 50 values of the antibacterial activity of the prepared materials for the inhibi...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2011-05, Vol.21 (10), p.2812-2815
Main Authors: Iwai, Noritaka, Nakayama, Kyosuke, Oku, Jumpei, Kitazume, Tomoya
Format: Article
Language:English
Subjects:
Aminocaproates - chemical synthesis
Aminocaproates - chemistry
Aminocaproates - pharmacology
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Assay
Biological and medical sciences
Biological Assay
CF 3–alaremycin derivatives
Chlorofluorocarbons, Methane - chemistry
IC 50
Inhibitory Concentration 50
Medical sciences
Molecular Structure
Pharmacology. Drug treatments
Porphobilinogen synthase
Porphobilinogen Synthase - antagonists & inhibitors
Porphobilinogen Synthase - chemistry
Pseudomonas - drug effects
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Summary:The preparation and the antibacterial activity of alaremycin derivatives such as their CF 3-derivatives and ( R)- and ( S)-4-oxo-5-acetylaminohexanoic acid for the porphobilinogen synthase (PBGS), were described. The IC 50 values of the antibacterial activity of the prepared materials for the inhibitor of PBGS, were determined using PBGS assay.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2011.03.106